3-Bromopyruvic acid

• CAT Number: I000450
• CAS Number: 1113-59-3
• Molecular Formula: C3H3BrO3
• Molecular Weight: 166.96
• Purity: ≥95%
• Target: hexokinase II
• Solubility: H2O: ≥ 32 mg/mL
• Storage: 3 years -20C powder
• IUPAC Name: 3-bromo-2-oxopropanoic acid
• InChI: InChI=1S/C3H3BrO3/c4-1-2(5)3(6)7/h1H2,(H,6,7)
• InChIKey: PRRZDZJYSJLDBS-UHFFFAOYSA-N
• SMILES: C(C(=O)C(=O)O)Br

3-Bromopyruvic acid (CAT: I000450) is a hexokinase II inhibitor. Hexokinase II is an enzyme involved in the first step of glycolysis, the conversion of glucose to glucose-6-phosphate. By inhibiting hexokinase II, 3-Bromopyruvic acid disrupts the glycolytic pathway in cancer cells, leading to a decrease in ATP production and ultimately causing cell death. Its effectiveness as an antitumor agent has been demonstrated in studies on hepatoma cells, showing its potential as a therapeutic approach for cancer treatment. However, further research is needed to evaluate its efficacy and safety in clinical settings.

Overview of Clinical Research

3-Bromopyruvic acid is an alkylating agent and a MASP2 inhibitor developed by Johns Hopkins University. The US FDA approved its application in liver cancer in 2013.

Reference

[1]. Gong L, et al. 3-Bromopyruvic acid, a hexokinase II inhibitor, is an effective antitumor agent on the hepatoma cells : in vitro and in vivo findings. Anticancer Agents Med Chem. 2014 Jun;14(5):771-6.
[2]. Sadowska-Bartosz I, et al. Anticancer agent 3-bromopyruvic acid forms a conjugate with glutathione. Pharmacol Rep. 2016 Apr;68(2):502-5.