WAY 316606

• CAT Number: I005461
• CAS Number: 915759-45-4
• Molecular Formula: C18H19F3N2O4S2
• Molecular Weight: 448.48
• Purity: ≥95%
• Target: sFRP-1
• Solubility: in DMSO > 10 mM
• Storage: Store at -20°C
• IC50: 80 nM (Kd); 0.65 uM (EC50)
• IUPAC Name: 5-(benzenesulfonyl)-N-piperidin-4-yl-2-(trifluoromethyl)benzenesulfonamide
• InChI: InChI=1S/C18H19F3N2O4S2/c19-18(20,21)16-7-6-15(28(24,25)14-4-2-1-3-5-14)12-17(16)29(26,27)23-13-8-10-22-11-9-13/h1-7,12-13,22-23H,8-11H2
• InChIKey: ITBGJNVZJBVPLJ-UHFFFAOYSA-N
• SMILES: C1CNCCC1NS(=O)(=O)C2=C(C=CC(=C2)S(=O)(=O)C3=CC=CC=C3)C(F)(F)F

WAY-316606(CAT: I005461) is a compound that has been investigated as a potential sFRP-1 (Secreted frizzled-related proteins) inhibitor. sFRP-1 is a secreted protein that can modulate the Wnt signaling pathway by binding to Wnt ligands and preventing their interaction with cell surface receptors. By inhibiting sFRP-1, WAY-316606 can potentially enhance Wnt signaling and have implications in various biological processes. It is worth noting that research on WAY-316606 and its effects on sFRP-1 inhibition is ongoing, and further studies are needed to fully understand its therapeutic potential.

Reference

[1]. Bodine, Peter V. N, et al. A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation. Bone (Amsterdam, Netherlands) (2009), 44(6), 1063-1068. 

[2]. Moore, William J, et al. Modulation of Wnt Signaling Through Inhibition of Secreted Frizzled-Related Protein I (sFRP-1) with N-Substituted Piperidinyl Diphenylsulfonyl Sulfonamides. Journal of Medicinal Chemistry (2009), 52(1), 105-116.