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WAY-262611

WAY-262611

  • CAT Number: I000464
  • CAS Number: 1123231-07-1
  • Molecular Formula: C20H22N4
  • Molecular Weight: 318.4
  • Purity: ≥95%
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<p style=/line-height:25px/>WAY-262611 is a wingless β-Catenin agonist that increases bone formation rate; with EC50 of 0.63 uM in TCF-Luciferase assay.<br>IC50 value: 0.63 uM (EC50 in TCF-Luciferase assay)<br>Target: β-Catenin agonist<br>WAY-262611 is acting via the Wnt β-catenin pathway and most likely through inhibition of Dkk-1. WAY-262611 has excellent pharmacokinetic properties and showed a dose dependent increase in the trabecular bone formation rate in ovariectomized rats following oral administration.</p>

Catalog Number I000464
CAS Number 1123231-07-1
Molecular Formula

C20H22N4

Purity 95%
Target Wnt/β-catenin
Solubility DMSO: ≥ 42 mg/mL
Storage Store at -20°C
IC50 0.63 uM (EC50 in TCF-Luciferase assay)
InChIKey QHLITPHIARVDJI-UHFFFAOYSA-N
Reference

<p style=/line-height:25px/>
<br>[1]. Pelletier JC, et al. (1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: a wingless beta-catenin agonist that increases bone formation rate. J Med Chem. 2009 Nov 26;52(22):6962-5.
</p>

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