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VUF 10166

VUF 10166

  • CAT Number: R058690
  • CAS Number: 155584-74-0
  • Molecular Formula: C13H15ClN4
  • Molecular Weight: 262.741
  • Purity: ≥95%
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VUF10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with K<sub>i</sub> of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower.<br>VUF10166 shows low activity to 5-HT<sub>3</sub>AB receptor with K<sub>i</sub> of 22 nM. VUF10166 may be used to can distinguish between 5-HT<sub>3</sub>A and 5-HT<sub>3</sub>AB receptors. VUF10166 has no activity to α7 nACh receptor. VUF10166 also acts as a partial agonist at 5-HT3A receptors with EC50 of 5.2 μM, which shows that VUF10166 is unlikely to bind in the receptor pore.

Catalog Number R058690
CAS Number 155584-74-0
Molecular Formula

C13H15ClN4

Purity 95%
Target 5-HT Receptor
Solubility Soluble in DMSO > 10 mM
Storage 3 years -20C powder
IUPAC Name 2-chloro-3-(4-methylpiperazin-1-yl)quinoxaline
InChI InChI=1S/C13H15ClN4/c1-17-6-8-18(9-7-17)13-12(14)15-10-4-2-3-5-11(10)16-13/h2-5H,6-9H2,1H3
InChIKey FFXVTQDGTKEXHF-UHFFFAOYSA-N
SMILES CN1CCN(CC1)C2=NC3=CC=CC=C3N=C2Cl

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