VU0810464(CAT: I017114) is a selective positive allosteric modulator of muscarinic acetylcholine receptor subtype 4 (M4). By binding to the M4 receptor, VU0810464 enhances the receptor’s response to acetylcholine, leading to increased signaling through the M4 pathway. This modulation of M4 receptor activity has been implicated in various physiological processes, including cognition, reward, and motor control. VU0810464 has shown potential therapeutic effects in preclinical studies for the treatment of neuropsychiatric disorders such as schizophrenia and Parkinson’s disease.
| Catalog Number | I017114 |
| CAS Number | 2126040-21-7 |
| Molecular Formula | C₁₈H₂₁ClFN₃O |
| Purity | 95% |
| Reference | [1]. Vo BN, et al. VU0810464, a non-urea G protein-gated inwardly rectifying K+ (Kir 3/GIRK) channel activator, exhibits enhanced selectivity for neuronal Kir 3 channels and reduces stress-induced hyperthermia in mice.Br J Pharmacol. 2019 Jul;176(13):2238-2249.<br>[2]. Wieting JM,et al. Discovery and Characterization of 1H-Pyrazol-5-yl-2-phenylacetamides as Novel, Non-Urea-Containing GIRK1/2 Potassium Channel Activators.ACS Chem Neurosci. 2017 Sep 20;8(9):1873-1879. |
