Ellipticine

• CAT Number: I003882
• CAS Number: 519-23-3
• Molecular Formula: C₁₇H₁₄N₂
• Molecular Weight: 246.31
• Purity: ≥95%
• Target: Topoisomerase
• Solubility: 10 mM in DMSO
• Storage: 2-8°C
• IC50: ＜ 1 μM (mean IC50) [1]
• IUPAC Name: 5,11-dimethyl-6H-pyrido[4,3-b]carbazole
• InChI: InChI=1S/C17H14N2/c1-10-14-9-18-8-7-12(14)11(2)17-16(10)13-5-3-4-6-15(13)19-17/h3-9,19H,1-2H3
• InChIKey: CTSPAMFJBXKSOY-UHFFFAOYSA-N
• SMILES: CC1=C2C=CN=CC2=C(C3=C1NC4=CC=CC=C43)C

Ellipticine (Cat No.: I003882) is a potent antineoplastic agent with significant therapeutic potential. It exerts its action by inhibiting the activity of DNA topoisomerase II, an enzyme critical for DNA replication and repair. When cells are treated with Ellipticine, it leads to the inhibition of cell growth and proliferation, making it valuable in cancer treatment. This effect is attributed to the formation of two covalent DNA adducts derived from Ellipticine, disrupting DNA structure and function within cancer cells. Researchers are actively studying Ellipticine for its role in cancer therapy and exploring its mechanisms of action for potential clinical applications. If you need to, please contact us in time, and we will reply to you as soon as possible within 24 hours.

Reference

1:Demonstration of a potent RET transcriptional inhibitor for the treatment of medullary thyroid carcinoma based on an ellipticine derivative. Kumarasamy VM, Sun D.Int J Oncol. 2017 May 11. doi: 10.3892/ijo.2017.3994. [Epub ahead of print] PMID: 28498409 2:Concise synthesis and antiproliferative activity evaluation of ellipticine quinone and its analogs. Nishiyama T, Hatae N, Mizutani M, Yoshimura T, Kitamura T, Miyano M, Fujii M, Satsuki N, Ishikura M, Hibino S, Choshi T.Eur J Med Chem. 2017 Apr 28;136:1-13. doi: 10.1016/j.ejmech.2017.04.071. [Epub ahead of print] PMID: 28477443 3:Effectiveness of human cytochrome P450 3A4 present in liposomal and microsomal nanoparticles in formation of covalent DNA adducts by ellipticine. Sulc M, Mrizova I, Cerna T, Frei E, Eckschlager T, Adam V, Kopeckova K, Stiborova M.Neuro Endocrinol Lett. 2016 Dec 18;37(Suppl1):95-102. PMID: 28263536 4:ATM participates in the regulation of viability and cell cycle via ellipticine in bladder cancer. Tao S, Meng S, Zheng X, Xie L.Mol Med Rep. 2017 Mar;15(3):1143-1148. doi: 10.3892/mmr.2017.6141. Epub 2017 Jan 24. PMID: 28138703 Free PMC Article5:Nuclear quantum effects in a HIV/cancer inhibitor: The case of ellipticine. Sappati S, Hassanali A, Gebauer R, Ghosh P.J Chem Phys. 2016 Nov 28;145(20):205102. PMID: 27908111 6:Retraction to /Ellipticine-induced apoptosis depends on Akt translocation and signaling in lung epithelial cancer cells/. Fang K, Chen SP, Lin CW, Cheng WC, Huang HT.Lung Cancer. 2016 Oct;100:120. doi: 10.1016/j.lungcan.2016.08.010. No abstract available. PMID: 27597291 7:Induced expression of microsomal cytochrome b5 determined at mRNA and protein levels in rats exposed to ellipticine, benzo[a]pyrene, and 1-phenylazo-2-naphthol (Sudan I). Stiborová M, Moserová M, Mrízová I, Dračínská H, Martínek V, Indra R, Frei E, Adam V, Kizek R, Schmeiser HH, Kubáčková K, Arlt VM.Monatsh Chem. 2016;147:897-904. Epub 2016 Jan 12. PMID: 27110040 Free PMC Article8:Heterologous expression of human cytochrome P450 2S1 in Escherichia coli and investigation of its role in metabolism of benzo[a]pyrene and ellipticine. Mrízová I, Moserová M, Milichovský J, Šulc M, Kizek R, Kubáčková K, Arlt VM, Stiborová M.Monatsh Chem. 2016;147:881-888. Epub 2016 Mar 30. PMID: 27110039 Free PMC Article9:Effect of Cholesterol on Cellular Uptake of Cancer Drugs Pirarubicin and Ellipticine. Zhang L, Bennett WF, Zheng T, Ouyang PK, Ouyang X, Qiu X, Luo A, Karttunen M, Chen P.J Phys Chem B. 2016 Mar 31;120(12):3148-56. doi: 10.1021/acs.jpcb.5b12337. Epub 2016 Mar 18. PMID: 26937690 10:Fluorescence Characterization of Gold Modified Liposomes with Antisense N-myc DNA Bound to the Magnetisable Particles with Encapsulated Anticancer Drugs (Doxorubicin, Ellipticine and Etoposide). Skalickova S, Nejdl L, Kudr J, Ruttkay-Nedecky B, Jimenez AM, Kopel P, Kremplova M, Masarik M, Stiborova M, Eckschlager T, Adam V, Kizek R.Sensors (Basel). 2016 Feb 25;16(3):290. doi: 10.3390/s16030290. PMID: 26927112 Free PMC Article