For research use only. Not for therapeutic Use.
VU0155069（Cat No.:I010673）is a selective positive allosteric modulator of the metabotropic glutamate receptor subtype 4 (mGluR4). By enhancing receptor sensitivity to glutamate, it amplifies signaling without directly activating the receptor, supporting normal synaptic transmission and neuroprotection. VU0155069 has been employed in studies of Parkinson’s disease and other neurological disorders, where mGluR4 modulation is thought to alleviate motor dysfunction and reduce excitotoxicity. Its selectivity and potency make it a valuable tool in probing glutamatergic pathways and exploring therapeutic strategies for neurodegenerative disease research.
| CAS Number | 1130067-06-9 |
| Synonyms | N-[(2S)-1-[4-(5-chloro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]propan-2-yl]naphthalene-2-carboxamide |
| Molecular Formula | C26H27ClN4O2 |
| Purity | ≥95% |
| IUPAC Name | N-[(2S)-1-[4-(5-chloro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]propan-2-yl]naphthalene-2-carboxamide |
| InChI | InChI=1S/C26H27ClN4O2/c1-17(28-25(32)20-7-6-18-4-2-3-5-19(18)14-20)16-30-12-10-22(11-13-30)31-24-9-8-21(27)15-23(24)29-26(31)33/h2-9,14-15,17,22H,10-13,16H2,1H3,(H,28,32)(H,29,33)/t17-/m0/s1 |
| InChIKey | DRIMIUYGTDAQOX-KRWDZBQOSA-N |
| SMILES | C[C@@H](CN1CCC(CC1)N2C3=C(C=C(C=C3)Cl)NC2=O)NC(=O)C4=CC5=CC=CC=C5C=C4 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
