Vps34-IN-1

• CAT Number: I001479
• CAS Number: 1383716-33-3
• Molecular Formula: C21H24ClN7O
• Molecular Weight: 425.9
• Purity: ≥95%
• Synonyms: 1-((2-((2-chloropyridin-4-yl)amino)-4/’-(cyclopropylmethyl)-[4,5/’-bipyrimidin]-2/’-yl)amino)-2-methylpropan-2-ol
• Target: Autophagy
• Solubility: DMSO: ≥ 31 mg/mL
• Storage: Store at -20°C
• IC50: 4 nM
• IUPAC Name: 1-[[5-[2-[(2-chloropyridin-4-yl)amino]pyrimidin-4-yl]-4-(cyclopropylmethyl)pyrimidin-2-yl]amino]-2-methylpropan-2-ol
• InChI: InChI=1S/C21H24ClN7O/c1-21(2,30)12-26-19-25-11-15(17(29-19)9-13-3-4-13)16-6-8-24-20(28-16)27-14-5-7-23-18(22)10-14/h5-8,10-11,13,30H,3-4,9,12H2,1-2H3,(H,25,26,29)(H,23,24,27,28)
• InChIKey: AWNXKZVIZARMME-UHFFFAOYSA-N
• SMILES: CC(C)(CNC1=NC=C(C(=N1)CC2CC2)C3=NC(=NC=C3)NC4=CC(=NC=C4)Cl)O

Vps34-IN-1 (CAT: I001479) is a potent and selective inhibitor of the class III phosphoinositide 3-kinase (PI3K) known as Vps34 (vacuolar protein sorting 34). Vps34 plays a crucial role in autophagy, a cellular process involved in the degradation and recycling of cellular components. By inhibiting Vps34, Vps34-IN-1 disrupts the autophagy pathway, leading to the accumulation of damaged proteins and organelles in cells. This compound has shown promising activity in preclinical studies as a potential therapeutic agent for the treatment of various diseases, including cancer, neurodegenerative disorders, and certain viral infections.

Reference

1. Cornella Taracido, et al. Preparation of bipyrimidinamine derivatives for use as Vps34 inhibitors. From PCT Int. Appl. (2012), WO 2012085815 A1 20120628.
2.Jaber, Nadia, et al. "Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function." Proceedings of the National Academy of Sciences 109.6 (2012): 2003-2008.