Voruciclib

• CAT Number: I010046
• CAS Number: 1000023-04-0
• Molecular Formula: C22H19ClF3NO5
• Molecular Weight: 469.84
• Purity: ≥95%
• Target: CDK4 inhibitor
• Solubility: Soluble in DMSO, not in water
• Storage: Store at -20°C
• IUPAC Name: 2-[2-chloro-4-(trifluoromethyl)phenyl]-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl]chromen-4-one
• InChI: InChI=1S/C22H19ClF3NO5/c1-27-5-4-12(14(27)9-28)19-15(29)7-16(30)20-17(31)8-18(32-21(19)20)11-3-2-10(6-13(11)23)22(24,25)26/h2-3,6-8,12,14,28-30H,4-5,9H2,1H3/t12-,14+/m1/s1
• InChIKey: MRPGRAKIAJJGMM-OCCSQVGLSA-N
• SMILES: CN1CCC(C1CO)C2=C(C=C(C3=C2OC(=CC3=O)C4=C(C=C(C=C4)C(F)(F)F)Cl)O)O

Voruciclib（Cat No.:I010046）, also referred to as P1446A-05, is a specific inhibitor of cyclin-dependent kinase 4 (CDK4), a protein kinase involved in cell cycle regulation. By inhibiting CDK4, voruciclib exhibits potential antineoplastic activity, targeting cancer cells that rely on CDK4-mediated cell cycle progression for their growth and proliferation. This inhibition can induce cell cycle arrest and inhibit tumor cell growth.

Reference

1:Eliades P, Miller DM, Miao B, Kumar R, Taylor M, Buch S, Srinivasa SP, Flaherty KT, Tsao H. A novel multi-CDK inhibitor P1446A-05 restricts melanoma growth and produces synergistic effects in combination with MAPK pathway inhibitors. Cancer Biol Ther. 2016 Jan 25:0. [Epub ahead of print] PubMed PMID: 26810603.2:Paiva C, Godbersen JC, Soderquist RS, Rowland T, Kilmarx S, Spurgeon SE, Brown JR, Srinivasa SP, Danilov AV. Cyclin-Dependent Kinase Inhibitor P1446A Induces Apoptosis in a JNK/p38 MAPK-Dependent Manner in Chronic Lymphocytic Leukemia B-Cells. PLoS One. 2015 Nov 25;10(11):e0143685. doi: 10.1371/journal.pone.0143685. eCollection 2015. PubMed PMID: 26606677; PubMed Central PMCID: PMC4659573.