Vortioxetine

• CAT Number: I003809
• CAS Number: 508233-74-7
• Molecular Formula: C18H22N2S
• Molecular Weight: 298.45
• Purity: ≥95%
• Target: 5-HT Receptor
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 15nM (5-HT1A); 33nM (5-HT1B); 3.7nM(5-HT3A); 19nM (5-HT7); 1.6 nM(SERT) [1]
• IUPAC Name: 1-[2-(2,4-dimethylphenyl)sulfanylphenyl]piperazine
• InChI: 1S/C18H22N2S/c1-14-7-8-17(15(2)13-14)21-18-6-4-3-5-16(18)20-11-9-19-10-12-20/h3-8,13,19H,9-12H2,1-2H3 Download
• InChIKey: YQNWZWMKLDQSAC-UHFFFAOYSA-N
• SMILES: CC1=CC(=C(C=C1)SC2=CC=CC=C2N3CCNCC3)C

Vortioxetine (Lu AA21004) (Cat.No:I003809) is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with IC50 of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively. Vortioxetine displayed antagonistic properties at 5-HT3A and 5-HT7 receptors, partial agonist properties at 5-HT1B receptors, agonistic properties at 5-HT1A receptors, and potent inhibition of SERT.

Reference

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