VO-OHpic, Trihydrate

• CAT Number: I003663
• CAS Number: 476310-60-8
• Molecular Formula: C₁₂H₁₆N₂O₁₁V
• Molecular Weight: 415.2
• Purity: ≥95%
• Target: PTEN
• Solubility: 10 mM in DMSO, H2O: ＜ 0.1 mg/mL
• Storage: Store at -20°C
• IUPAC Name: 3-hydroxypyridine-2-carboxylic acid;oxovanadium;trihydrate
• InChI: InChI=1S/2C6H5NO3.3H2O.O.V/c2*8-4-2-1-3-7-5(4)6(9)10;;;;;/h2*1-3,8H,(H,9,10);3*1H2
• InChIKey: RHVLCDIRYQMAQQ-UHFFFAOYSA-N
• SMILES: C1=CC(=C(N=C1)C(=O)O)O.C1=CC(=C(N=C1)C(=O)O)O.O.O.O.O=[V]

VO-Ohpic（Cat No.:I003663） is a highly potent inhibitor of PTEN (phosphatase and tensin homolog), with an IC50 value of 35 nM. PTEN is a critical tumor suppressor protein involved in regulating cell growth, proliferation, and survival pathways. By inhibiting PTEN, VO-Ohpic can potentially dysregulate these pathways, leading to altered cellular processes and potentially promoting tumor growth. The potent inhibitory activity of VO-Ohpic against PTEN highlights its potential as a valuable tool compound for studying PTEN-related signaling pathways and as a potential therapeutic target for various diseases, including cancer.

Reference

[1]. Rosivatz, E., et al., A small molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN). ACS Chem. Biol. 1, 780-790, (2006)
[2]. Mak LH, Vilar R, Woscholski R. Characterisation of the PTEN inhibitor VO-OHpic. J Chem Biol. 2010 Oct;3(4):157-63.
[3]. Zu L, Shen Z, Wesley J, Cai ZP. PTEN inhibitors cause a negative inotropic and chronotropic effect in mice. Eur J Pharmacol. 2011 Jan 10;650(1):298-302.