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VLX600

VLX600

  • CAT Number: R026987
  • CAS Number: 327031-55-0
  • Molecular Formula: C17H15N7
  • Molecular Weight: 317.356
  • Purity: ≥95%
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VLX600 is a compound that shows selective cytotoxicity against quiescent cancer cells (IC<sub>50</sub> = 1-10 µM) with selectivity for malignant cells. It induces necrosis in non-proliferating quiescent core cells in multicellular spheroids (MCs) formed from HCT116 colon cancer cells. VLX600 induces the expression of genes associated with hypoxia, glycolysis, and p53 signaling, stimulates autophagy, and triggers mitochondrial dysfunction in MCs. It displays antitumor activity against colon cancer xenografts with minimal systemic toxicity in mice.

Catalog Number R026987
CAS Number 327031-55-0
Molecular Formula

C17H15N7

Purity 95%
Storage -20°C
IUPAC Name 6-methyl-N-[(E)-1-pyridin-2-ylethylideneamino]-5H-[1,2,4]triazino[5,6-b]indol-3-amine
InChI InChI=1S/C17H15N7/c1-10-6-5-7-12-14(10)19-16-15(12)22-24-17(20-16)23-21-11(2)13-8-3-4-9-18-13/h3-9H,1-2H3,(H2,19,20,23,24)/b21-11+
InChIKey UQOSBPRTQFFUOA-SRZZPIQSSA-N
SMILES CC1=CC=CC2=C1NC3=C2N=NC(=N3)NN=C(C)C4=CC=CC=N4

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