Vincristine sulfate

• CAT Number: A001110
• CAS Number: 2068-78-2
• Molecular Formula: C46H56N4O10 • H2SO4
• Molecular Weight: 923
• Purity: ≥95%
• Target: Microtubule/Tubulin
• Solubility: >46.2mg/mL in DMSO
• Storage: 3 years -20C powder
• InChIKey: AQTQHPDCURKLKT-PNYVAJAMSA-N

Vincristine sulfate is the sulfate salt of a natural alkaloid isolated from the plant Vinca rosea Linn with antimitotic and antineoplastic activities. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis.

Reference

1:Hyaluronic acid-coated cationic nanostructured lipid carriers for oral vincristine sulfate delivery. Gao X, Zhang J, Xu Q, Huang Z, Wang Y, Shen Q.Drug Dev Ind Pharm. 2017 Apr;43(4):661-667. doi: 10.1080/03639045.2016.1275671. Epub 2017 Jan 8. PMID: 28043185 2:The influence of different long-circulating materials on the pharmacokinetics of liposomal vincristine sulfate. Zhang J, Chen Y, Li X, Liang X, Luo X.Int J Nanomedicine. 2016 Aug 26;11:4187-97. doi: 10.2147/IJN.S109547. eCollection 2016. PMID: 27616886 Free PMC Article3:Efficacy and Safety of Vincristine Sulfate Liposome Injection in the Treatment of Adult Acute Lymphocytic Leukemia. Douer D.Oncologist. 2016 Jul;21(7):840-7. doi: 10.1634/theoncologist.2015-0391. Epub 2016 Jun 21. Review. PMID: 27328933 4:Vincristine Sulfate Liposomes Injection (VSLI, Marqibo®): Results From a Phase I Study in Children, Adolescents, and Young Adults With Refractory Solid Tumors or Leukemias. Shah NN, Merchant MS, Cole DE, Jayaprakash N, Bernstein D, Delbrook C, Richards K, Widemann BC, Wayne AS.Pediatr Blood Cancer. 2016 Jun;63(6):997-1005. doi: 10.1002/pbc.25937. Epub 2016 Feb 17. PMID: 26891067 5:Vincristine sulfate loaded dextran microspheres amalgamated with thermosensitive gel offered sustained release and enhanced cytotoxicity in THP-1, human leukemia cells: In vitro and in vivo study. Thakur V, Kush P, Pandey RS, Jain UK, Chandra R, Madan J.Mater Sci Eng C Mater Biol Appl. 2016 Apr 1;61:113-22. doi: 10.1016/j.msec.2015.12.015. Epub 2015 Dec 12. PMID: 26838831 6:Plasma and cerebrospinal fluid pharmacokinetics of vincristine and vincristine sulfate liposomes injection (VSLI, marqibo®) after intravenous administration in Non-human primates. Shah NN, Cole DE, Lester-McCully CM, Wayne AS, Warren KE, Widemann BC.Invest New Drugs. 2016 Feb;34(1):61-5. doi: 10.1007/s10637-015-0311-x. Epub 2015 Dec 10. PMID: 26661090 7:Delivery of vincristine sulfate-conjugated gold nanoparticles using liposomes: a light-responsive nanocarrier with enhanced antitumor efficiency. Liu Y, He M, Niu M, Zhao Y, Zhu Y, Li Z, Feng N.Int J Nanomedicine. 2015 Apr 22;10:3081-95. doi: 10.2147/IJN.S79550. eCollection 2015. PMID: 25960649 Free PMC Article8:Clinical pharmacokinetics and effects of vincristine sulfate in dogs with transmissible venereal tumor (TVT). Hantrakul S, Klangkaew N, Kunakornsawat S, Tansatit T, Poapolathep A, Kumagai S, Poapolathep S.J Vet Med Sci. 2014 Dec;76(12):1549-53. doi: 10.1292/jvms.14-0180. Epub 2014 Aug 21. PMID: 25649934 Free PMC Article9:Validation of an UPLC-MS-MS Method for Quantitative Analysis of Vincristine in Human Urine After Intravenous Administration of Vincristine Sulfate Liposome Injection. Yang F, Wang H, Hu P, Jiang J.J Chromatogr Sci. 2015 Jul;53(6):974-8. doi: 10.1093/chromsci/bmu164. Epub 2014 Dec 17. PMID: 25520304 10:Preparation of vincristine sulfate-loaded poly (butylcyanoacrylate) nanoparticles modified with pluronic F127 and evaluation of their lymphatic tissue targeting. Tan R, Niu M, Zhao J, Liu Y, Feng N.J Drug Target. 2014 Jul;22(6):509-17. doi: 10.3109/1061186X.2014.897708. Epub 2014 Mar 13. PMID: 24625287