Vinblastine

• CAT Number: I005196
• CAS Number: 865-21-4
• Molecular Formula: C46H58N4O9
• Molecular Weight: 810.97
• Purity: ≥95%
• Target: Microtubule/nAChR
• Solubility: DMSO: ≥ 42 mg/mL
• Storage: Store at -20°C
• IC50: VIN showed EC50 values of 15 ug/ml, against P815 mastocytoma cells in-vitro[1]. Also supresses nAChR activity with IC50 of 8.9 μM.
• IUPAC Name: methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate
• InChI: InChI=1S/C46H58N4O9/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3/t28-,37-,38+,39+,42-,43+,44+,45-,46-/m0/s1
• InChIKey: JXLYSJRDGCGARV-CFWMRBGOSA-N
• SMILES: CC[C@@]1(C[C@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O

Vinblastine (Cat.No:I005196) is a natural chemotherapy medication derived from the Madagascar periwinkle plant. It plays a crucial role in treating various cancers, including Hodgkin’s disease and lymphomas. Acting as a microtubule-disrupting agent, Vinblastine impedes cell division, inhibiting tumor growth. However, its usage must be carefully managed due to potential side effects.

Reference

[1]. Exposure to paclitaxel or vinblastine down-regulates CD11a and CD54 expression by P815 mastocytoma cells and renders the tumor cells resistant to killing by nonspecific cytotoxic T lymphocytes induced with anti-CD3 antibody.
[2]. MiyamotoK, TakedaK, KogaK,Antitumour effects and pharmacokinetics of combination of vinblastine with a staurosporine derivative, NA-382, inP388/ADR-bearing mice. J Pharm Pharmacol. 1995 Jun;47(6):524-9.
[3]. Hilgendorf C, Doeppenschmitt S. In vitro metabolism of vinblastine: inhibition of CYP3A4 mediated nifedipine oxidation but not testosterone-6-beta hydroxylation. Eur.J.Clin.Pharmacol., 2001, 57, No. 8, A31