Vildagliptin-d7

• CAT Number: R067124
• CAS Number: 1133208-42-0
• Molecular Formula: C17H18D7N3O2
• Molecular Weight: 310.4
• Purity: ≥95%
• Synonyms: (2S)-1-[2-[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]-2-pyrrolidine-2,3,3,4,4,5,5-d7-carbonitrile
• Storage: 2°C to 8°C
• InChI: InChI=1S/C17H25N3O2/c18-9-14-2-1-3-20(14)15(21)10-19-16-5-12-4-13(6-16)8-17(22,7-12)11-16/h12-14,19,22H,1-8,10-11H2/t12?,13?,14?,16-,17-/i1D2,2D2,3D2,14D
• InChIKey: SYOKIDBDQMKNDQ-IUSGACIYSA-N
• SMILES: O=C(CN[C@@]1(CC(C2)C3)CC3C[C@]2(O)C1)N4[C@]([2H])(C#N)C([2H])([2H])C([2H])([2H])C4([2H])[2H]

Vildagliptin-d7 has 7 deuteriums. Vildagliptin-d7 is intended for use as an internal standard for the quantification of vildagliptin (Item No. 14705) by GC- or LC-MS. Vildagliptin is an inhibitor of DPP-4 (IC50 = 3.5-34 nM). It also inhibits DPP-8 and DPP-9 (Ki = 810 and 95 nM, respectively) but not DPP-2 or the related fibroblast activation protein α. Through its effects on DPP-4, it blocks the degradation of several circulating peptides, including incretins (stimulators of insulin secretion) like glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1. Vildagliptin reduces fasting and postprandial glucose levels and decreases inflammatory and oxidative stress in diverse animal models of disease.

Reference

1.Weber, A.E. Dipeptidyl peptidase IV inhibitors for the treatment of diabetes. Journal of Medicinal Chemistry 47(17), 4135-4141 (2004).