For research use only. Not for therapeutic Use.
Vevorisertib trihydrochloride (Cat No.:I044670) is a potent, selective allosteric inhibitor of AKT, a key serine/threonine kinase involved in the PI3K/AKT/mTOR signaling pathway. By targeting AKT1, AKT2, and AKT3 isoforms, vevorisertib disrupts survival and proliferation signals in tumor cells with aberrant PI3K/AKT pathway activation. It is particularly effective in cancers harboring AKT mutations or PTEN loss. Vevorisertib trihydrochloride has demonstrated antitumor activity in preclinical and early clinical studies, showing potential as a targeted therapy for solid tumors with dysregulated AKT signaling.
| CAS Number | 1416775-08-0 |
| Synonyms | N-[1-[3-[3-[4-(1-aminocyclobutyl)phenyl]-2-(2-aminopyridin-3-yl)imidazo[4,5-b]pyridin-5-yl]phenyl]piperidin-4-yl]-N-methylacetamide;trihydrochloride |
| Molecular Formula | C35H41Cl3N8O |
| Purity | ≥95% |
| IUPAC Name | N-[1-[3-[3-[4-(1-aminocyclobutyl)phenyl]-2-(2-aminopyridin-3-yl)imidazo[4,5-b]pyridin-5-yl]phenyl]piperidin-4-yl]-N-methylacetamide;trihydrochloride |
| InChI | InChI=1S/C35H38N8O.3ClH/c1-23(44)41(2)26-15-20-42(21-16-26)28-7-3-6-24(22-28)30-13-14-31-34(39-30)43(33(40-31)29-8-4-19-38-32(29)36)27-11-9-25(10-12-27)35(37)17-5-18-35;;;/h3-4,6-14,19,22,26H,5,15-18,20-21,37H2,1-2H3,(H2,36,38);3*1H |
| InChIKey | HNFNJTGXAZHZSB-UHFFFAOYSA-N |
| SMILES | CC(=O)N(C)C1CCN(CC1)C2=CC=CC(=C2)C3=NC4=C(C=C3)N=C(N4C5=CC=C(C=C5)C6(CCC6)N)C7=C(N=CC=C7)N.Cl.Cl.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
