ML-210

• CAT Number: I011957
• CAS Number: 1360705-96-9
• Molecular Formula: C22H20Cl2N4O4
• Molecular Weight: 475.32
• Purity: ≥95%
• Solubility: Soluble in DMSO
• Storage: Store at 2-8 °C
• IUPAC Name: [4-[bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone
• InChI: InChI=1S/C22H20Cl2N4O4/c1-14-20(28(30)31)19(25-32-14)22(29)27-12-10-26(11-13-27)21(15-2-6-17(23)7-3-15)16-4-8-18(24)9-5-16/h2-9,21H,10-13H2,1H3
• InChIKey: VIBHJPDPEVVDTB-UHFFFAOYSA-N
• SMILES: O=C(N1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)CC1)C4=NOC(C)=C4[N+]([O-])=O

ML-210 (Cat.No:I011957), also known as CID 49766530, is a potent and selective RAS inhibitor. ML-210 displayed nanomolar potency in the primary screening cell line while maintaining selectivity similar to previously identified probes. The probe is in a novel structural class in the field of RAS synthetically lethal compounds and will, therefore, be highly useful in identifying pathways that can potentially be used for selectively inhibiting cancer cells.

Reference

1: Bittker JA, Weiwer M, Lewis T, Shimada K, Yang WS, MacPherson L, Dandapani S, Munoz B, Palmer M, Stockwell BR, Schreiber SL. Screen for RAS-Selective Lethal Compounds and VDAC Ligands – Probe 2. 2011 Feb 10 [updated 2011 Dec 12]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available from http://www.ncbi.nlm.nih.gov/books/NBK98919/ PubMed PMID: 22834036.2: Devarajan R, Ashraf M, Beck RO, Lemberger RJ, Taylor MC. Holmium: YAG lasertripsy for ureteric calculi: an experience of 300 procedures. Br J Urol. 1998 Sep;82(3):342-7. PubMed PMID: 9772868.3: Weïwer M, Bittker JA, Lewis TA, Shimada K, Yang WS, MacPherson L, Dandapani S, Palmer M, Stockwell BR, Schreiber SL, Munoz B. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1822-6. doi: 10.1016/j.bmcl.2011.09.047. Epub 2011 Sep 28. PubMed PMID: 22297109; PubMed Central PMCID: PMC3528973.