VERRUCULOGEN

  • CAT Number: M059380
  • CAS Number: 12771-72-1
  • Molecular Formula: C27H33N3O7
  • Molecular Weight: 511.6
  • Purity: ≥95%
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Verruculogen is a tremorgenic mycotoxin, affecting CNS functions, arresting mammary carcinoma cells in vitro, affecting potassium channels. Verruculogen decreases GABA levels in CNS. Tremorgenic doses of verruculogen increase the number and decrease the affinity of DHP receptors in rat cortex. Verruculogen is a potent inhibitor of high conductance Ca activated K (maxi-K) channel.

Catalog Number M059380
CAS Number 12771-72-1
Molecular Formula

C27H33N3O7

Purity 95%
Target Potassium Channel
Solubility Soluble in DMSO
Storage Store at -20°C
InChIKey LRXYHMMJJCTUMY-GWXUGYLUSA-N
Reference

Tremorgenic toxin from Penicillium veruculosum. Cole R.J., et al. Appl. Microbiol. 1972, 24, 248.<br/><br/>The strucuture of verruculogen. A tremor producing epoxide from Penicillium verruculosum. Fayos J. et al. , J. Am. Chem. Soc. 1974, 96, 6785.<br/><br/>Actions of tremorgenic fungal toxins on neurotransmitter release. Norris P.J. et al. , J. Neurochem. 1980, 34, 33.<br/><br/>Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. Knaus H.H. et al. , Biochemistry 1994, 33, 5819.<br/><br/>Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. II. Physico-chemical properties and structures. Cui C.B. et al. , J. Antibiot. 1996, 49, 534. <br/><br/>In vitro effects of tremorgenic mycotoxins. Selala M.I. et al. , J. Nat. Prod. 1991, 54, 207.</span></p>

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