VERATROYLZYGADENINE

• CAT Number: T000133
• CAS Number: 31329-58-5
• Molecular Formula: C36H51NO10
• Purity: ≥95%
• Solubility: In chloroform and methanol pyridineNot well in ethanol, chloroform, water, acetone
• Storage: Store at +4C, in dark place. Stable in freeze-dried state. Stable several months in solution.

As an analog of Veratridine, it is a Na+ channel activator and a potent neurotoxic. Indeed, it is a depolarizing agent on membranes of nerve terminal, muscle and gland cells.Steroid alkaloid<!–C<SUB>36</SUB>H<SUB>51</SUB>NO<SUB>10</SUB>–>, from plants of the <I>Veratrum </I>genus, LiliaceaeIt has an effect on cardiac vessel system at the dosage of 1-50 μg/kg (i.v.)

Reference

– Kupchan. /Veratrum alkaloids. XXX. The structure and configuration of zygadenine./ J. Amer. Chem. Soc. (1959). 81:1925- Fink et al., /Veratridine and other depolarizing agents counteract the inhibitory effect of Mg++ ion…/Nannyn-Schmiedeberg�s Arch. Pharmacol. (1990). 342N(1):53-60- Tarvin et al., /Glucose induced electrical activity in the pancreatic beta-cells: effect of veratridine./ Amer. J. Physiol. (1981). 240:127-134- Honerjager, /A neutrally mediated inotropic effect of veratridine and sevadine on isolated guinea pig papillary muscle./ Nannyn Schmiederberg/’s Arch. Pharmacol. (1980). 314:157-160