Verapamil hydrochloride Buy (CAS Number: 152-11-4)

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CAT Number: A000837
CAS Number: 152-11-4
Molecular Formula: C27H38N2O4.HCl
Molecular Weight: 491.07
Purity: ≥95%

Verapamil hydrochloride ( CAS 152-11-4) is the hydrochloride form of Verapamil, which is a phenylalkylamine calcium channel blocking agent. Verapamil inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents.

Catalog Number	A000837
CAS Number	152-11-4
Molecular Formula	C27H38N2O4.HCl
Purity	95%
Target	Calcium Channel
Solubility	>14.5mg/mL in DMSO
Storage	Store at -20C
IUPAC Name	2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile;hydrochloride
InChI	InChI=1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H
InChIKey	DOQPXTMNIUCOSY-UHFFFAOYSA-N
SMILES	CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC.Cl
Reference	<p> <span style="color:#000000;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:12px;">1.<span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">McTavish, Donna, and Eugene M. Sorkin. "Verapamil." </span><i style="font-family: Arial, sans-serif; font-size: 13px; font-variant-ligatures: normal; orphans: 2; widows: 2;">Drugs</i><span style="font-variant-ligatures: normal; orphans: 2; widows: 2;"> 38.1 (1989): 19-76.<br /> 2.</span><span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">Singh, Bramah N., Gray Ellrodt, and C. Thomas Peter. "Verapamil: a review of its pharmacological properties and therapeutic use." </span><i style="font-family: Arial, sans-serif; font-size: 13px; font-variant-ligatures: normal; orphans: 2; widows: 2;">Drugs</i><span style="font-variant-ligatures: normal; orphans: 2; widows: 2;"> 15.3 (1978): 169-197.<br /> 3.</span><span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">Wang, Feihu, et al. "Synergistic effect of folate-mediated targeting and verapamil-mediated P-gp inhibition with paclitaxel-polymer micelles to overcome multi-drug resistance." </span><i style="font-family: Arial, sans-serif; font-size: 13px; font-variant-ligatures: normal; orphans: 2; widows: 2;">Biomaterials</i><span style="font-variant-ligatures: normal; orphans: 2; widows: 2;"> 32.35 (2011): 9444-9456.<br /> 4.</span><span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">Futscher, Bernard W., et al. "Verapamil suppresses the emergence of P‐glycoprotein‐mediated multi‐drug resistance." </span><i style="font-family: Arial, sans-serif; font-size: 13px; font-variant-ligatures: normal; orphans: 2; widows: 2;">International journal of cancer</i><span style="font-variant-ligatures: normal; orphans: 2; widows: 2;"> 66.4 (1996): 520-525.</span></span></span></span></p>

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