VER-50589

• CAT Number: I004774
• CAS Number: 747413-08-7
• Molecular Formula: C19H17ClN2O5
• Molecular Weight: 388.8
• Purity: ≥95%
• Target: Hsp90
• Solubility: DMSO: ≥ 48 mg/mL
• Storage: -20°C
• IC50: 21 nM
• InChIKey: JXPCDMPJCKNLBY-UHFFFAOYSA-N

VER-50589 (Cat No.:I004774) is a small molecule inhibitor of the deubiquitinase USP7, which is involved in the regulation of various cellular processes, including DNA damage response and immune signaling. By inhibiting USP7, VER-50589 can stabilize tumor suppressor proteins such as p53 and promote their activation, leading to growth inhibition and apoptosis in cancer cells. VER-50589 has shown efficacy in preclinical studies and may have therapeutic potential in cancer treatment.

Reference

[1]. Sharp SY, et al. Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues. Mol Cancer Ther. 2007 Apr;6(4):1198-211.
[2]. Gaspar N, et al. Acquired resistance to 17-allylamino-17-demethoxygeldanamycin (17-AAG, tanespimycin) in glioblastoma cells. Cancer Res. 2009 Mar 1;69(5):1966-75.