Velneperit

• CAT Number: I003246
• CAS Number: 342577-38-2
• Molecular Formula: C17H24F3N3O3S
• Molecular Weight: 407.45
• Purity: ≥95%
• Target: neuropeptide Y receptor
• Solubility: DMSO: ≥ 30 mg/mL
• Storage: Store at -20°C
• IUPAC Name: 4-(tert-butylsulfonylamino)-N-[5-(trifluoromethyl)pyridin-2-yl]cyclohexane-1-carboxamide
• InChI: InChI=1S/C17H24F3N3O3S/c1-16(2,3)27(25,26)23-13-7-4-11(5-8-13)15(24)22-14-9-6-12(10-21-14)17(18,19)20/h6,9-11,13,23H,4-5,7-8H2,1-3H3,(H,21,22,24)
• InChIKey: WGEWUYACXPEFPO-UHFFFAOYSA-N
• SMILES: CC(C)(C)S(=O)(=O)NC1CCC(CC1)C(=O)NC2=NC=C(C=C2)C(F)(F)F

Velneperit（Cat No.:I003246）, also known as S-2367, is a novel antagonist of the neuropeptide Y (NPY) Y5 receptor. It selectively blocks the binding of NPY to the Y5 receptor, thereby inhibiting its signaling pathways. The NPY Y5 receptor is involved in the regulation of various physiological processes, including appetite, energy homeostasis, and cardiovascular function. By antagonizing the Y5 receptor, Velneperit has the potential to modulate these pathways, making it a promising candidate for the development of therapies targeting conditions such as obesity, metabolic disorders, and cardiovascular diseases.

Reference

[1]. Shinichi Oda*, et al. Development of an Optimized Synthetic and Purification Process of S-2367 (Velneperit), a Novel Neuropeptide Y (NPY) Y5 Receptor Antagonist. Org. Process Res. Dev., 2015, 19 (4), pp 531-536.