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Valganciclovir HCl

Valganciclovir HCl

  • CAT Number: A000622
  • CAS Number: 175865-59-5
  • Molecular Formula: C14H22N6O5 • HCl
  • Molecular Weight: 390.8
  • Purity: ≥95%
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<span style="font-size:12px;"><span style="font-family:arial,helvetica,sans-serif;">Valganciclovir (CAS 175865-59-5)&nbsp;is a L-valyl ester (prodrug) of ganciclovir that exists as a mixture of two diastereomers, with antiviral activity. After oral administration, both diastereomers are rapidly converted to ganciclovir by intestinal and hepatic esterases. Ganciclovir is a synthetic analogue of 2/&#39;-deoxyguanosine, which inhibits replication of human CMV in cell culture and in vivo. The reported EC50 values of ganciclovir that inhibit human CMV replication in cell culture (laboratory and clinical isolates) have ranged from 0.08 to 22.94 &mu;M (0.02 to 5.75 mcg/mL).</span></span>

Catalog Number A000622
CAS Number 175865-59-5
Molecular Formula

C14H22N6O5 • HCl

Purity 95%
Target CMV
Solubility >11.4mg/mL in DMSO
Storage Store at -20C
IUPAC Name [2-[(2-amino-6-oxo-1H-purin-9-yl)methoxy]-3-hydroxypropyl] (2S)-2-amino-3-methylbutanoate;hydrochloride
InChI InChI=1S/C14H22N6O5.ClH/c1-7(2)9(15)13(23)24-4-8(3-21)25-6-20-5-17-10-11(20)18-14(16)19-12(10)22;/h5,7-9,21H,3-4,6,15H2,1-2H3,(H3,16,18,19,22);1H/t8?,9-;/m0./s1
InChIKey ZORWARFPXPVJLW-MTFPJWTKSA-N
SMILES CC(C)C(C(=O)OCC(CO)OCN1C=NC2=C1N=C(NC2=O)N)N.Cl
Reference

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