UVI 3003

• CAT Number: I010736
• CAS Number: 847239-17-2
• Molecular Formula: C28H36O4
• Molecular Weight: 436.59
• Purity: ≥95%
• Synonyms: 3-[4-Hydroxy-3-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-(pentyloxy)-2-naphthalenyl]phenyl]-2-propenoic acid
• Target: Retinoid X Receptors
• Solubility: Soluble to 100 mM in DMSO and to 100 mM in ethanol
• Storage: -20°C
• IUPAC Name: (E)-3-[4-hydroxy-3-(5,5,8,8-tetramethyl-3-pentoxy-6,7-dihydronaphthalen-2-yl)phenyl]prop-2-enoic acid
• InChI: InChI=1S/C28H36O4/c1-6-7-8-15-32-25-18-23-22(27(2,3)13-14-28(23,4)5)17-21(25)20-16-19(9-11-24(20)29)10-12-26(30)31/h9-12,16-18,29H,6-8,13-15H2,1-5H3,(H,30,31)/b12-10+
• InChIKey: APJSHECCIRQQDV-ZRDIBKRKSA-N
• SMILES: CCCCCOC1=CC2=C(C=C1C3=C(C=CC(=C3)C=CC(=O)O)O)C(CCC2(C)C)(C)C

UVI 3003（Cat No.:I010736） is a potent retinoid X receptor (RXR) inhibitor, exhibiting high selectivity. It effectively inhibits the activities of RXRα in both Xenopus laevis and human cells. In Cos7 cells, UVI 3003 demonstrates IC50 values of 0.22 μM and 0.24 μM for Xenopus laevis and human RXRα, respectively. As an RXR inhibitor, UVI 3003 offers potential applications in the study of RXR-related biological processes and as a tool compound for investigating retinoid signaling pathways.