USP14 Inhibitor, IU1

• CAT Number: R061143
• CAS Number: 314245-33-5
• Molecular Formula: C₁₈H₂₁FN₂O
• Molecular Weight: 300.37
• Purity: ≥95%
• Target: DUB
• Solubility: >10.9mg/mL in DMSO
• Storage: Store at 4°C
• InChI: InChI=1S/C18H21FN2O/c1-13-11-17(18(22)12-20-9-3-4-10-20)14(2)21(13)16-7-5-15(19)6-8-16/h5-8,11H,3-4,9-10,12H2,1-2H3
• InChIKey: JUWDSDKJBMFLHE-UHFFFAOYSA-N
• SMILES: CC1=CC(=C(N1C2=CC=C(C=C2)F)C)C(=O)CN3CCCC3

IU1 is a selective USP14 inhibitor. IU1 prevents ventilator-induced lung injury in rats. IU1 inhibits the catalytic activity of proteasome-associated Usp14 in vitro (IC50 < 4 μM). IU1 stimulates proteasome activity and substrate degradation. USP14 removes the ubiquitin chain of I-κB, therefore inducing I-κB degradation and increasing cytokine release.

Reference

1:Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: Relevance to Alzheimer/’s disease. Kiprowska MJ, Stepanova A, Todaro DR, Galkin A, Haas A, Wilson SM, Figueiredo-Pereira ME.Biochim Biophys Acta. 2017 Apr 1;1863(6):1157-1170. doi: 10.1016/j.bbadis.2017.03.017. [Epub ahead of print] PMID: 28372990 2:USP14 inhibitor IU1 prevents ventilator-induced lung injury in rats. Xu YH, Guo NL.Cell Mol Biol (Noisy-le-grand). 2014 Sep 7;60(2):50-4. PMID: 25198582