UPCDC-30245

• CAT Number: I037863
• CAS Number: 1883351-01-6
• Molecular Formula: C28H38FN5
• Molecular Weight: 463.63
• Purity: ≥95%
• Synonyms: 1-[3-(5-fluoro-1H-indol-2-yl)phenyl]-N-[2-(4-propan-2-ylpiperazin-1-yl)ethyl]piperidin-4-amine
• InChI: InChI=1S/C28H38FN5/c1-21(2)33-16-14-32(15-17-33)13-10-30-25-8-11-34(12-9-25)26-5-3-4-22(19-26)28-20-23-18-24(29)6-7-27(23)31-28/h3-7,18-21,25,30-31H,8-17H2,1-2H3
• InChIKey: LZHXZCVDLATFAR-UHFFFAOYSA-N
• SMILES: CC(C)N1CCN(CC1)CCNC2CCN(CC2)C3=CC=CC(=C3)C4=CC5=C(N4)C=CC(=C5)F

UPCDC-30245 (Cat No.: I037863) is a potent and selective inhibitor of the bile salt export pump (BSEP/ABCB11), a liver-specific transporter responsible for secreting bile acids into the bile canaliculi. By blocking BSEP activity, UPCDC-30245 is used to model cholestasis in vitro and in vivo, enabling the study of bile acid–mediated liver injury. It is valuable in drug safety and hepatotoxicity research to identify compounds with BSEP inhibition risk. UPCDC-30245 supports investigations into bile acid metabolism, liver function, and mechanisms underlying cholestatic liver diseases.

Reference

[1]. Banerjee S, et al. 2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition. Science. 2016 Feb 19;351(6275):871-5.
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[2]. Wang F, et al. Allosteric p97 Inhibitors Can Overcome Resistance to ATP-Competitive p97 Inhibitors for Potential Anticancer Therapy. ChemMedChem. 2020 Apr 20;15(8):685-694.
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[3]. Wang F, et al. Temporal proteomics reveal specific cell cycle oncoprotein downregulation by p97/VCP inhibition. Cell Chem Biol. 2021 Nov 23:S2451-9456(21)00482-7.
[Content Brief]