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UNC3866

UNC3866

  • CAT Number: I002422
  • CAS Number: 1872382-47-2
  • Molecular Formula: C43H66N6O8
  • Molecular Weight: 795
  • Purity: ≥95%
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UNC3866 (CAT: I002422) is a potent antagonist that targets the CBX7-H3 interaction. It has been determined through AlphaScreen analysis to have an IC50 value of 66±1.2 nM. UNC3866 demonstrates high selectivity for CBX7 over other members of the methyl-lysine (Kme) reader panel, with more than 100-fold selectivity observed. CBX7 is a protein involved in recognizing and binding to specific methylated lysine residues, playing a role in chromatin regulation and gene expression. UNC3866’s ability to selectively disrupt the CBX7-H3 interaction offers potential applications in epigenetic research and the development of therapies targeting CBX7-related processes.

Catalog Number I002422
CAS Number 1872382-47-2
Molecular Formula

C43H66N6O8

Purity 95%
Target 66±1.2 nM (CBX7)[1]
Solubility DMSO: ≥ 27 mg/mL
Storage -20°C
InChIKey UMRRDXVUROEIKJ-JCXBGQGISA-N
Reference

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<br>[1]. Stuckey JI, et al. A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1. Nat Chem Biol. 2016 Mar;12(3):180-7.

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