For research use only. Not for therapeutic Use.
UCB-6876(CAT: I037764) is a novel small-molecule inhibitor of tumor necrosis factor-alpha (TNFα), a central cytokine in inflammatory and autoimmune disorders. It uniquely binds to the asymmetrical crystal form of the TNF trimer, disrupting trimer stability and interfering with TNFα receptor interactions. By targeting this specific structural conformation, UCB-6876 effectively inhibits TNFα-mediated signaling, offering a distinct mechanism from traditional biologics. This compound is valuable for studying TNFα structure-function relationships, cytokine signaling, and the development of next-generation anti-inflammatory therapeutics. UCB-6876 is ideal for in vitro and in vivo studies exploring novel approaches to modulate TNFα activity in immune-related diseases.
| CAS Number | 637324-45-9 |
| Synonyms | [1-[(2,5-dimethylphenyl)methyl]benzimidazol-2-yl]methanol |
| Molecular Formula | C17H18N2O |
| Purity | ≥95% |
| IUPAC Name | [1-[(2,5-dimethylphenyl)methyl]benzimidazol-2-yl]methanol |
| InChI | InChI=1S/C17H18N2O/c1-12-7-8-13(2)14(9-12)10-19-16-6-4-3-5-15(16)18-17(19)11-20/h3-9,20H,10-11H2,1-2H3 |
| InChIKey | RZRPPZWEPMDGEI-UHFFFAOYSA-N |
| SMILES | CC1=CC(=C(C=C1)C)CN2C3=CC=CC=C3N=C2CO |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
