UBP-310

• CAT Number: I009923
• CAS Number: 902464-46-4
• Molecular Formula: C14H14N3O6S+
• Molecular Weight: 352.341
• Purity: ≥95%
• Synonyms: UBP310; UBP 310; UBP-310.;(S)-3-((3-(2-amino-2-carboxyethyl)-5-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)methyl)thiophene-2-carboxylic acid
• Target: Kainate Receptors
• Solubility: Soluble in DMSO, not in water
• Storage: Store at 4 °C
• IC50: 130 nM
• IUPAC Name: 3-[[3-(2-amino-2-carboxyethyl)-5-methylidene-2,6-dioxopyrimidin-3-ium-1-yl]methyl]thiophene-2-carboxylic acid
• InChI: InChI=1S/C14H13N3O6S/c1-7-4-16(6-9(15)12(19)20)14(23)17(11(7)18)5-8-2-3-24-10(8)13(21)22/h2-4,9H,1,5-6,15H2,(H-,19,20,21,22)/p+1
• InChIKey: JKFBXNLABOXGTM-UHFFFAOYSA-O
• SMILES: C=C1C=[N+](C(=O)N(C1=O)CC2=C(SC=C2)C(=O)O)CC(C(=O)O)N

UBP-310 is a potent and selective GLUK5 kainate receptor antagonist (IC50 = 130 nM). UBP-310also blocks recombinant homomeric GLUK7 receptors.

Reference

1:Buldyrev I, Puthussery T, Taylor WR. Synaptic pathways that shape the excitatory drive in an OFF retinal ganglion cell. J Neurophysiol. 2012 Apr;107(7):1795-807. doi: 10.1152/jn.00924.2011. Epub 2011 Dec 28. PubMed PMID: 22205648; PubMed Central PMCID: PMC3331668.2:Atlason PT, Scholefield CL, Eaves RJ, Mayo-Martin MB, Jane DE, Molnár E. Mapping the ligand binding sites of kainate receptors: molecular determinants of subunit-selective binding of the antagonist [3H]UBP310. Mol Pharmacol. 2010 Dec;78(6):1036-45. doi: 10.1124/mol.110.067934. Epub 2010 Sep 13. PubMed PMID: 20837679; PubMed Central PMCID: PMC2993462.