UAMC-3203 hydrochloride

• CAT Number: I019212
• CAS Number: 2271358-65-5
• Molecular Formula: C₂₅H₃₈ClN₅O₂S
• Molecular Weight: 508.12
• Purity: ≥95%
• Storage: 4°C, away from moisture and light
• IUPAC Name: 3-(benzylamino)-4-(cyclohexylamino)-N-(2-piperazin-1-ylethyl)benzenesulfonamide;hydrochloride
• InChI: InChI=1S/C25H37N5O2S.ClH/c31-33(32,28-15-18-30-16-13-26-14-17-30)23-11-12-24(29-22-9-5-2-6-10-22)25(19-23)27-20-21-7-3-1-4-8-21;/h1,3-4,7-8,11-12,19,22,26-29H,2,5-6,9-10,13-18,20H2;1H
• InChIKey: WBZHHIZXEXJBSM-UHFFFAOYSA-N
• SMILES: C1CCC(CC1)NC2=C(C=C(C=C2)S(=O)(=O)NCCN3CCNCC3)NCC4=CC=CC=C4.Cl

UAMC-3203 hydrochloride（Cat No.:I019212） is a powerful and selective inhibitor of ferroptosis, a form of regulated cell death characterized by iron-dependent lipid peroxidation. It displays a remarkable inhibitory potency, with an IC50 value of 12 nM. By targeting ferroptosis, UAMC-3203 hydrochloride has the potential to modulate cell death processes in various pathological conditions, including cancer and neurodegenerative diseases. Its high selectivity ensures minimal interference with other cellular processes. Further research and development of UAMC-3203 hydrochloride may lead to new therapeutic strategies for diseases associated with ferroptosis.

Reference

[1]. Devisscher L, et al. Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy. J Med Chem. 2018 Nov 21;61(22):10126-10140.