U-73122

• CAT Number: I000478
• CAS Number: 112648-68-7
• Molecular Formula: C₂₉H₄₀N₂O₃
• Molecular Weight: 464.64
• Purity: ≥95%
• Target: 5-Lipoxygenase
• Solubility: DMSO: ＜ 4.8 mg/mL
• Storage: Store at -20C
• IUPAC Name: 1-[6-[[(8R,9S,13S,14S,17S)-3-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]amino]hexyl]pyrrole-2,5-dione
• InChI: InChI=1S/C29H40N2O3/c1-29-16-15-23-22-10-8-21(34-2)19-20(22)7-9-24(23)25(29)11-12-26(29)30-17-5-3-4-6-18-31-27(32)13-14-28(31)33/h8,10,13-14,19,23-26,30H,3-7,9,11-12,15-18H2,1-2H3/t23-,24-,25+,26+,29+/m1/s1
• InChIKey: LUFAORPFSVMJIW-ZRJUGLEFSA-N
• SMILES: CC12CCC3C(C1CCC2NCCCCCCN4C(=O)C=CC4=O)CCC5=C3C=CC(=C5)OC

U-73122 (Cat No.:I000478) is also called 1 – [6 – [[(8R, 9S, 13S, 14S, 17S) – 3-methoxy-13-methyl-6,7,8,9,11,12,14,15,17-decahydrocyclopentane [a] phenanthrene-17-yl] amino] hexyl] pyrrol-2,5-dione. U73122 is a powerful phospholipase C (PLC) inhibitor, which can reduce the increase of calcium 2+in platelets and neutrophils induced by agonists. U73122 can effectively inhibit human 5-lipoxygenase (5-LO).

Reference

1. Smith RJ, et al. Receptor-coupled signal transduction in human polymorphonuclear neutrophils: effects of a novel inhibitor of phospholipase C-dependent processes on cell responsiveness. J Pharmacol Exp Ther. 1990 May;253(2):688-97.
2. Bleasdale JE, et al. Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils. J Pharmacol Exp Ther. 1990 Nov;255(2):756-68.
3. Thompson AK, et al. The aminosteroid U-73122 inhibits muscarinic receptor sequestration and phosphoinositide hydrolysis in SK-N-SH neuroblastoma cells. A role for Gp in receptor compartmentation. J Biol Chem. 1991 Dec 15;266(35):23856-62.
4. Yule DI, et al. U73122 inhibits Ca2+ oscillations in response to cholecystokinin and carbachol but not to JMV-180 in rat pancreatic acinar cells. J Biol Chem. 1992 Jul 15;267(20):13830-5.