U-104

• CAT Number: I002315
• CAS Number: 178606-66-1
• Molecular Formula: C₁₃H₁₂FN₃O₃S
• Molecular Weight: 309.32
• Purity: ≥95%
• Target: Carbonic anhydrase inhibitor
• Solubility: DMSO: ≥ 47 mg/mL
• Storage: 3 years -20C powder
• IC50: 45.1 nM/4.5 nM(Ki, CA IX/CA XII) [1]
• InChI: InChI=1S/C13H12FN3O3S/c14-9-1-3-10(4-2-9)16-13(18)17-11-5-7-12(8-6-11)21(15,19)20/h1-8H,(H2,15,19,20)(H2,16,17,18)
• InChIKey: YJQZNWPYLCNRLP-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1NC(=O)NC2=CC=C(C=C2)S(=O)(=O)N)F

U-104 (CAT: I002315) is a potent inhibitor of carbonic anhydrase (CA), specifically targeting CA IX and CA XII with high affinity. It exhibits a binding constant (Ki) of 45.1 nM for CA IX and 4.5 nM for CA XII. While it effectively inhibits the activity of CA IX and CA XII, U-104 demonstrates relatively low inhibition towards CA I and CA II. By selectively targeting CA IX and CA XII, U-104 may have potential applications in cancer therapy, as these isoforms of carbonic anhydrase are often overexpressed in various types of tumors and play roles in maintaining the tumor microenvironment.

Reference

[1]. Lou Y, et al. Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. Cancer Res. 2011 May 1;71(9):3364-76.
[2]. Lock FE, et al. Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche. Oncogene. 2013 Oct 31;32(44):5210-9.