TY-52156

• CAT Number: I005546
• CAS Number: 934369-14-9
• Molecular Formula: C18H19Cl2N3O
• Molecular Weight: 364.27
• Purity: ≥95%
• Target: S1P receptor inhibitor
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 110 nM (Ki)
• IUPAC Name: N-(4-chloroanilino)-N/'-(4-chlorophenyl)-3,3-dimethyl-2-oxobutanimidamide
• InChI: InChI=1S/C18H19Cl2N3O/c1-18(2,3)16(24)17(21-14-8-4-12(19)5-9-14)23-22-15-10-6-13(20)7-11-15/h4-11,22H,1-3H3,(H,21,23)
• InChIKey: XONRRGIRSGNWFP-UHFFFAOYSA-N
• SMILES: CC(C)(C)C(=O)C(=NC1=CC=C(C=C1)Cl)NNC2=CC=C(C=C2)Cl

TY-52156 (CAT: I005546) is a potent antagonist of the S1P3 receptor. It exerts its inhibitory effects on the S1P3 receptor in a competitive manner, meaning it competes with the natural ligand for binding to the receptor. The estimated Ki value for TY-52156’s binding affinity to the S1P3 receptor is approximately 110 nM. S1P3 receptors are a subtype of sphingosine-1-phosphate (S1P) receptors that play important roles in various cellular processes, including immune cell regulation and vascular function. By antagonizing the S1P3 receptor, TY-52156 holds potential in modulating S1P3 receptor-mediated signaling and may have implications in the treatment of diseases and conditions where S1P3 receptor activity is dysregulated.

Reference

[1]. Murakami A, et al. Sphingosine 1-phosphate (S1P) regulates vascular contraction via S1P3 receptor: investigation based on a new S1P3 receptor antagonist. Mol Pharmacol. 2010 Apr;77(4):704-13.