TW-37

• CAT Number: I005282
• CAS Number: 877877-35-5
• Molecular Formula: C₃₃H₃₅NO₆S
• Molecular Weight: 573.7
• Purity: ≥95%
• Target: Bcl-2 Family
• Solubility: DMSO: ≥ 42 mg/mL
• Storage: 3 years -20C powder
• IC50: 0.29 μM (Ki for Bcl-2)
• InChI: InChI=1S/C33H35NO6S/c1-20(2)25-11-7-6-10-21(25)18-22-19-26(30(36)31(37)29(22)35)32(38)34-23-14-16-24(17-15-23)41(39,40)28-13-9-8-12-27(28)33(3,4)5/h6-17,19-20,35-37H,18H2,1-5H3,(H,34,38)
• InChIKey: PQAPVTKIEGUPRN-UHFFFAOYSA-N
• SMILES: CC(C)C1=CC=CC=C1CC2=C(C(=C(C(=C2)C(=O)NC3=CC=C(C=C3)S(=O)(=O)C4=CC=CC=C4C(C)(C)C)O)O)O

TW-37 (Cat.No:I005282) is a synthetic small molecule that exhibits anticancer properties. It functions as a potent inhibitor of multiple anti-apoptotic proteins, including Bcl-2, Bcl-xL, and Mcl-1, promoting apoptosis in cancer cells. TW-37 has shown promise in preclinical studies as a potential therapeutic agent for various types of cancer.

Reference

1:Data on the DNA damaging and mutagenic potential of the BH3-mimetics ABT-263/Navitoclax and TW-37. Green MM, Shekhar TM, Hawkins CJ.Data Brief. 2016 Jan 16;6:710-4. doi: 10.1016/j.dib.2016.01.013. eCollection 2016 Mar. PMID: 26958630 Free PMC Article2:Small-molecule inhibitor of Bcl-2 (TW-37) suppresses growth and enhances cisplatin-induced apoptosis in ovarian cancer cells. Wang H, Zhang Z, Wei X, Dai R.J Ovarian Res. 2015 Feb 20;8:3. doi: 10.1186/s13048-015-0130-x. PMID: 25823945 Free PMC Article3:Metronomic small molecule inhibitor of Bcl-2 (TW-37) is antiangiogenic and potentiates the antitumor effect of ionizing radiation. Zeitlin BD, Spalding AC, Campos MS, Ashimori N, Dong Z, Wang S, Lawrence TS, Nör JE.Int J Radiat Oncol Biol Phys. 2010 Nov 1;78(3):879-87. doi: 10.1016/j.ijrobp.2010.04.024. Epub 2010 Aug 1. PMID: 20675079 Free PMC Article4:TW-37, a small-molecule inhibitor of Bcl-2, mediates S-phase cell cycle arrest and suppresses head and neck tumor angiogenesis. Ashimori N, Zeitlin BD, Zhang Z, Warner K, Turkienicz IM, Spalding AC, Teknos TN, Wang S, Nör JE.Mol Cancer Ther. 2009 Apr;8(4):893-903. doi: 10.1158/1535-7163.MCT-08-1078. PMID: 19372562 Free PMC Article5:TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer: involvement of Notch-1 signaling pathway. Wang Z, Azmi AS, Ahmad A, Banerjee S, Wang S, Sarkar FH, Mohammad RM.Cancer Res. 2009 Apr 1;69(7):2757-65. doi: 10.1158/0008-5472.CAN-08-3060. Epub 2009 Mar 24. PMID: 19318573 Free PMC Article6:SMI of Bcl-2 TW-37 is active across a spectrum of B-cell tumors irrespective of their proliferative and differentiation status. Al-Katib AM, Sun Y, Goustin AS, Azmi AS, Chen B, Aboukameel A, Mohammad RM.J Hematol Oncol. 2009 Feb 16;2:8. doi: 10.1186/1756-8722-2-8. PMID: 19220884 Free PMC Article7:TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and invasion in pancreatic cancer. Wang Z, Song W, Aboukameel A, Mohammad M, Wang G, Banerjee S, Kong D, Wang S, Sarkar FH, Mohammad RM.Int J Cancer. 2008 Aug 15;123(4):958-66. doi: 10.1002/ijc.23610. Retraction in: Int J Cancer. 2016 Nov 1;139(9):2146. PMID: 18528859 Free PMC Article8:Preclinical studies of TW-37, a new nonpeptidic small-molecule inhibitor of Bcl-2, in diffuse large cell lymphoma xenograft model reveal drug action on both Bcl-2 and Mcl-1. Mohammad RM, Goustin AS, Aboukameel A, Chen B, Banerjee S, Wang G, Nikolovska-Coleska Z, Wang S, Al-Katib A.Clin Cancer Res. 2007 Apr 1;13(7):2226-35. PMID: 17404107 Free Article