TVP1022

• CAT Number: I002394
• CAS Number: 185517-74-2
• Molecular Formula: C12H13N
• Molecular Weight: 171.24
• Purity: ≥95%
• Target: Monoamine Oxidase
• Solubility: DMSO: ≥ 38 mg/mL
• Storage: -20°C
• IUPAC Name: (1S)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine
• InChI: 1S/C12H13N/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12/h1,3-6,12-13H,7-9H2/t12-/m0/s1
• InChIKey: RUOKEQAAGRXIBM-LBPRGKRZSA-N
• SMILES: C#CCN[C@H]1CCC2=CC=CC=C12

TVP1022 (Cat No.: I002394) is the S-enantiomer of rasagiline, originally developed as a neuroprotective and cardioprotective agent. It modulates mitochondrial function and inhibits apoptosis, making it a candidate for treating neurodegenerative and cardiovascular diseases. TVP1022 exhibits cytoprotective effects without significant monoamine oxidase B (MAO-B) inhibition, distinguishing it from rasagiline. Preclinical studies have shown potential benefits in myocardial infarction, heart failure, and neuronal injury models. Though not yet approved for clinical use, it remains of interest in research on cell survival and mitochondrial pathways.

Reference

[1]. Ertracht O, et al. The cardioprotective efficacy of TVP1022 in a rat model of ischaemia/reperfusion. Br J Pharmacol. 2011 Jun;163(4):755-69.
[2]. Berdichevski A, et al. TVP1022 protects neonatal rat ventricular myocytes against doxorubicin-induced functional derangements. J Pharmacol Exp Ther. 2010 Feb;332(2):413-20.