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Tubastatin A

Tubastatin A

  • CAT Number: R050536
  • CAS Number: 1239262-52-2
  • Molecular Formula: C₂₀H₂₁N₃O₂.HCl
  • Molecular Weight: 371.86
  • Purity: ≥95%
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Tubastatin A is a potent HDAC6 inhibitor with an IC<sub>50</sub> value of 15 nM. Comparatively, it demonstrates over 1,000-<wbr></wbr>fold selectivity against all other HDAC isoforms (IC<sub>50</sub>s &gt;16 μM), excluding HDAC8 (IC<sub>50</sub> = 0.9 μM). Tubastatin A induces α-<wbr></wbr>tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, tubastatin A displays dose-<wbr></wbr>dependent neuronal protection of primary cortical neuron cultures at 5-<wbr></wbr>10 μM.

Catalog Number R050536
CAS Number 1239262-52-2
Molecular Formula

C₂₀H₂₁N₃O₂.HCl

Purity 95%
Storage -20°C
InChI InChI=1S/C20H21N3O2.ClH/c1-22-11-10-19-17(13-22)16-4-2-3-5-18(16)23(19)12-14-6-8-15(9-7-14)20(24)21-25;/h2-9,25H,10-13H2,1H3,(H,21,24);1H
InChIKey LJTSJTWIMOGKRJ-UHFFFAOYSA-N
SMILES CN1CCC2=C(C1)C3=CC=CC=C3N2CC4=CC=C(C=C4)C(=O)NO.Cl

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