TTNPB

• CAT Number: I004665
• CAS Number: 71441-28-6
• Molecular Formula: C24H28O2
• Molecular Weight: 348.5
• Purity: ≥95%
• Synonyms: 4-[(E)-2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)prop-1-enyl]benzoic acid
• Target: RARs
• Solubility: DMSO: ≥ 11.25 mg/mL
• Storage: -20°C
• InChI: InChI=1S/C24H28O2/c1-16(14-17-6-8-18(9-7-17)22(25)26)19-10-11-20-21(15-19)24(4,5)13-12-23(20,2)3/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)/b16-14+
• InChIKey: FOIVPCKZDPCJJY-JQIJEIRASA-N
• SMILES: CC(=CC1=CC=C(C=C1)C(=O)O)C2=CC3=C(C=C2)C(CCC3(C)C)(C)C

TTNPB（Cat No.:I004665）, also known as Arotinoid Acid or AGN191183, is a potent agonist of retinoic acid receptors (RARs). It exhibits high affinity for human RARα, RARβ, and RARγ, with IC50 values of 5.1 nM, 4.5 nM, and 9.3 nM, respectively. By binding to RARs, TTNPB activates retinoic acid signaling pathways, which play crucial roles in cellular differentiation, proliferation, and development. The potent RAR agonistic activity of TTNPB makes it a valuable tool in studying retinoid-mediated cellular processes and potential therapeutic applications in diseases involving dysregulated retinoid signaling.

Reference

[1]. Pignatello MA, et al. Multiple factors contribute to the toxicity of the aromatic retinoid, TTNPB (Ro 13-7410): binding affinities and disposition. Toxicol Appl Pharmacol. 1997 Feb;142(2):319-27.
[2]. Pignatello MA, et al. Multiple factors contribute to the toxicity of the aromatic retinoid TTNPB (Ro 13-7410): interactions with the retinoic acid receptors. Toxicol Appl Pharmacol. 1999, 159(2), 109-116.
[3]. Darro F, et al. Growth inhibition of human in vitro and mouse in vitro and in vivo mammary tumor models by retinoids in comparison with tamoxifen and the RU-486 anti-progestagen. Breast Cancer Res Treat. 1998 Sep;51(1):39-55.