Tropisetron

• CAT Number: I005360
• CAS Number: 89565-68-4
• Molecular Formula: C17H20N2O2
• Molecular Weight: 284.35
• Purity: ≥95%
• Target: 5-HT3 receptor
• Solubility: DMSO 35 mg/ml; Water 64 mg/ml
• Storage: Store at -20C
• IC50: 70.1 ± 0.9 nM [1]

Tropisetron (Cat.No:I005360) is a serotonin 5-HT3 receptor antagonist used primarily to prevent nausea and vomiting caused by chemotherapy and radiation therapy. It works by blocking serotonin receptors in the gastrointestinal tract and central nervous system. Tropisetron is an effective antiemetic medication and is well-tolerated in clinical use.

Reference

[1]. Macor JE, et al. The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective alpha7 nicotinic receptor partial agonist.
Bioorg Med Chem Lett. 2001 Feb 12;11(3):319-21.

[2]. Vega Lde L, et al. The 5-HT3 receptor antagonist tropisetron inhibits T cell activation by targeting the calcineurin pathway. Biochem Pharmacol. 2005 Aug 1;70(3):369-80.

[3]. Stratz C, et al. The anti-inflammatory effects of the 5-HT? receptor antagonist tropisetron are mediated by the inhibition of p38 MAPK activation in primary human monocytes. Int Immunopharmacol. 2012 Aug;13(4):398-402.

[4]. Candelario-Jalil E, et al. Detrimental effects of tropisetron on permanent ischemic stroke in the rat. BMC Neurosci. 2008 Feb 6;9:19.