Triptonide

• CAT Number: I003418
• CAS Number: 38647-11-9
• Molecular Formula: C20H22O6
• Molecular Weight: 358.39
• Purity: ≥95%
• Target: dCTP Pyrophosphatase
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: (1S,2S,4S,5S,7S,9S,11S,13S)-1-methyl-7-propan-2-yl-3,6,10,16-tetraoxaheptacyclo[11.7.0.02,4.02,9.05,7.09,11.014,18]icos-14(18)-ene-8,17-dione
• InChI: InChI=1S/C20H22O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14H,4-7H2,1-3H3/t11-,12-,13-,14-,17-,18-,19+,20+/m0/s1
• InChIKey: SWOVVKGLGOOUKI-ZHGGVEMFSA-N
• SMILES: CC(C)[C@@]12[C@@H](O1)[C@H]3[C@@]4(O3)[C@]5(CCC6=C([C@@H]5C[C@H]7[C@]4(C2=O)O7)COC6=O)C

Triptonide (Cat.No:I003418) is a natural diterpenoid compound found in the Thunder God Vine (Tripterygium wilfordii). It possesses anti-inflammatory, immunosuppressive, and anticancer properties. Triptonide has shown promising potential in preclinical studies for its ability to inhibit inflammatory responses and induce cell cycle arrest and apoptosis in cancer cells. 

Reference

[1]. Corson, Timothy W.; Cavga, Hueseyin; Aberle, Nicholas; Crews, Craig M. Triptolide Directly Inhibits dCTP Pyrophosphatase. ChemBioChem (2011), 12(11), 1767-1773.
[2]. Wu YW, Jiang YY, Xiao TX, Zhang HL.Determination of triptonide by cloud point extraction combined with MEKC.J Sep Sci. 2008 Mar;31(5):865-71.
[3]. Yao J, Zhang L, Zhao X, Hu L, Jiang Z.Simultaneous determination of triptolide, wilforlide A and triptonide in human plasma by high-performance liquid chromatography-electrospray ionization mass spectrometry.Biol Pharm Bull. 2006 Jul;29(7):1483-6.
[4]. Wang Z, Wen J, Xing J, Guo D.Determination of triptolide and triptonide in human plasma by high-performance liquid chromatography.Biomed Chromatogr. 2005 Jan;19(1):60-2.
[5]. Wang L, Ye W, Hui L, Liu X, Guo Y.[Male contraception of triptonide and its function mechanism].Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2000 Jun;22(3):223-6.