Trimetrexate glucuronate

• CAT Number: I037525
• CAS Number: 82952-64-5
• Molecular Formula: C25H33N5O10
• Molecular Weight: 563.56
• Purity: 98%
• Solubility: To be determined
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 2,4-Diamino-5-methyl-6-((3,4,5-trimethoxyanilino)methyl)quinazoline mono-D-glucuronate
• InChI: InChI=1S/C19H23N5O3.C6H10O7/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3;7-1-2(8)3(9)4(10)5(11)6(12)13/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24);1-5,8-11H,(H,12,13)/t;2-,3+,4-,5-/m.0/s1
• InChIKey: ZCJXQWYMBJYJNB-LRDBBFHQSA-N
• SMILES: COC1=C(OC)C(OC)=CC(NCC2=C(C)C3=C(N)N=C(N)N=C3C=C2)=C1.O=C[C@@H]([C@H]([C@@H]([C@@H](C(O)=O)O)O)O)O

Trimetrexate glucuronate is a nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.

Reference

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