Trimethylsilyl Cyanide

• CAT Number: R042001
• CAS Number: 7677-24-9
• Molecular Formula: C4H9NSi
• Molecular Weight: 99.21
• Purity: ≥95%
• Synonyms: Cyanotrimethylsilane; Trimethylcyanosilane; Trimethylsilanecarbonitrile; Trimethylsilyl nitrile; Trimethylsilylcarbonitrile
• Storage: -20°C
• IUPAC Name: trimethylsilylformonitrile
• InChI: InChI=1S/C4H9NSi/c1-6(2,3)4-5/h1-3H3
• InChIKey: LEIMLDGFXIOXMT-UHFFFAOYSA-N
• SMILES: C[Si](C)(C)C#N

Trimethylsilyl cyanide (Cat No.:R042001) is a volatile, colorless liquid. It serves as a versatile reagent in organic synthesis, primarily used to introduce cyano groups into carbonyl compounds, forming cyanohydrins under mild conditions. TMSCN is favored over traditional cyanide sources due to its improved handling and reduced volatility compared to hydrogen cyanide. However, it remains highly toxic and flammable, requiring careful storage and protective measures during use. It is commonly employed in pharmaceutical, agrochemical, and fine chemical industries for building nitrile-containing intermediates and complex molecules.