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Trimethylolpropane Phosphate

Trimethylolpropane Phosphate

  • CAT Number: R029287
  • CAS Number: 1005-93-2
  • Molecular Formula: C6H11O4P
  • Molecular Weight: 178.124
  • Purity: ≥95%
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<p>It is a neuronal voltage-dependent and GABA-gated Cl- channels blocker. It is also a non-competitive GABA antagonist and it causes epileptoform seizures.</p><br />Organophosphorous compound<!–C<SUB>6</SUB>H<SUB>11</SUB>O<SUB>4</SUB>P–>, synthetic</br><p>Cl- channel total blocking concentration: (IC<sub>100</sub>) ~ 50 nM (<em>Lymnaea stagnalis</em>);<br />(IC&lt;sub&gt;50&lt;/sub&gt;) for [&lt;sup&gt;3&lt;/sup&gt;H]-dihydropicrotoxin binding with rat brain membrane P2 fraction: 5.0 &amp;mu;M (Ticku M.);<br /><br />(IC&lt;sub&gt;50&lt;/sub&gt;) for [&lt;sup&gt;35&lt;/sup&gt;S]-tert.butyl-thionebicyclophosphate binding with human brain membranes : 5.9 &amp;mu;M (Casida J.);<br /> <br />experiments with [3H]-labelled GABA-competitive ligands (Muscimol, Funitrazepam) showed no influence of Etbicyphat up to 10 &amp;mu;M.</p></br>

Catalog Number R029287
CAS Number 1005-93-2
Molecular Formula

C6H11O4P

Purity 95%
Storage -20°C
IUPAC Name 4-ethyl-2,6,7-trioxa-1$l^{5}
InChI InChI=1S/C6H11O4P/c1-2-6-3-8-11(7,9-4-6)10-5-6/h2-5H2,1H3
InChIKey BYEFHDZWRALTEN-UHFFFAOYSA-N
SMILES CCC12COP(=O)(OC1)OC2
Reference

– Bellet et al., <I>Science</I>.(1973) 182:1135-1136<br /><br />- Cooper G. H. et al., Eur. J. Med. Chem. (1978). 13:207-212<br /><br />- Fetisov et al., Biol. Membr. (1986) (Russian). 3(5):968-970<br /><br />- Squires et al., <I>Mol. Pharmacol.</I>(1983) 23:326-331<br /><br /><br /><br />

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