Trimethoprim-d3

• CAT Number: R009533
• CAS Number: 1189923-38-3
• Molecular Formula: C14H18N4O3
• Molecular Weight: 293.341
• Purity: ≥95%
• Synonyms: 5-[(3,4,5-Trimethoxy-d3-phenyl)methyl]-2,4-pyrimidinediamine; 2,4-Diamino-5-(3’,4’,5’-trimethoxy-d3-benzyl)pyrimidine; Instalac-d3; Monotrim-d3; Proloprim-d3; Syraprim-d3; Tiempe-d3; Trimanyl-d3; Uretrim-d3; Wellcoprim-d3
• Storage: -20°C
• IUPAC Name: 5-[[3,5-dimethoxy-4-(trideuteriomethoxy)phenyl]methyl]pyrimidine-2,4-diamine
• InChI: InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)/i3D3
• InChIKey: IEDVJHCEMCRBQM-HPRDVNIFSA-N
• SMILES: COC1=CC(=CC(=C1OC)OC)CC2=CN=C(N=C2N)N

Trimethoprim-d3(CAT: R009533) is a deuterated form of the antibiotic drug Trimethoprim. Its action target involves inhibiting bacterial dihydrofolate reductase, an enzyme critical for the synthesis of folate, an essential precursor for DNA synthesis in bacteria. The mode of action disrupts bacterial folate metabolism, leading to inhibition of bacterial growth and replication. Pharmacologically, Trimethoprim-d3 exhibits the same antibacterial properties as non-deuterated Trimethoprim, effectively treating various bacterial infections. As a deuterated compound, it is used as an internal standard for quantification in pharmacokinetic and bioavailability studies of Trimethoprim, offering improved accuracy and precision in analytical measurements.