Triflusal

• CAT Number: A000196
• CAS Number: 322-79-2
• Molecular Formula: C10H7F3O4
• Molecular Weight: 248.16
• Purity: ≥95%
• Synonyms: UR1501
• Target: COX-1
• Solubility: Soluble in DMSO > 10 mM
• Storage: -20°C
• InChI: 1S/C10H7F3O4/c1-5(14)17-8-4-6(10(11,12)13)2-3-7(8)9(15)16/h2-4H,1H3,(H,15,16)
• InChIKey: RMWVZGDJPAKBDE-UHFFFAOYSA-N
• SMILES: CC(=O)OC1=C(C=CC(=C1)C(F)(F)F)C(=O)O

Triflusal (Cat.No:A000196) is a platelet aggregation inhibitor. It is a drug of the salicylate family but it is not a derivative of acetylsalicylic acid (ASA). Triflusal is indicated for the prevention of cardiovascular events such as stroke, acute treatment of cerebral infarction and myocardial infarction, and thromboprophylaxis due to atrial fibrillation.

Reference

1: Han SW, Kim YJ, Ahn SH, Seo WK, Yu S, Oh SH, Nam HS, Choi HY, Yoon SS, Kim SH,
Lee JY, Lee JH, Hwang YH, Lee KO, Jung YH, Lee J, Sohn SI, Kim YN, Lee KA,
Bushnell CD, Lee KY. Effects of Triflusal and Clopidogrel on the Secondary
Prevention of Stroke Based on Cytochrome P450 2C19 Genotyping. J Stroke. 2017
Sep;19(3):356-364. doi: 10.5853/jos.2017.01249. Epub 2017 Sep 29. PubMed PMID:
29037010; PubMed Central PMCID: PMC5647640.

2: Fuertes Ferre G, Laita Monreal S, Ortas Nadal MDR, Sánchez Insa E, Sánchez
Rubio-Lezcano J, Galache Osuna JG. Triflusal in Patients With Aspirin
Hypersensitivity Treated With Coronary Stent Implantation. Rev Esp Cardiol (Engl
Ed). 2017 May 27. pii: S1885-5857(17)30274-8. doi: 10.1016/j.rec.2017.05.007.
[Epub ahead of print] English, Spanish. PubMed PMID: 28559091.

3: Kim SW, Choi KJ, Park JY, Yoon SH, Lee JK. Neuroprotective effect of triflusal
and its main metabolite, 2-hydroxy-4-trifluoromethylbenzoic acid (HTB), in the
postischemic brain. Neurosci Lett. 2017 Mar 16;643:59-64. doi:
10.1016/j.neulet.2017.02.018. Epub 2017 Feb 9. PubMed PMID: 28189746.

4: Nuin E, Pérez-Sala D, Lhiaubet-Vallet V, Andreu I, Miranda MA.
Photosensitivity to Triflusal: Formation of a Photoadduct with Ubiquitin
Demonstrated by Photophysical and Proteomic Techniques. Front Pharmacol. 2016 Aug
29;7:277. doi: 10.3389/fphar.2016.00277. eCollection 2016. PubMed PMID: 27621705;
PubMed Central PMCID: PMC5002410.

5: Martínez Leboráns L, Cubells Sánchez L, Zaragoza Ninet V, Pérez Ferriols A.
Atypical photosensitivity associated with triflusal. Contact Dermatitis. 2016
Oct;75(4):245-7. doi: 10.1111/cod.12609. PubMed PMID: 27620122.

6: Han SW, Kim YJ, Ahn SH, Seo WK, Yu S, Oh SH, Kim YN, Lee KY; MAESTRO Study
Investigators. Protocol for the comparison of triflusal and clopidogrel in
secondary prevention of stroke based on cytochrome P450 2C19 genotyping (MASETRO
study): A multicenter, randomized, open-label, parallel-group trial. Int J
Stroke. 2016 Jun;11(4):485-91. doi: 10.1177/1747493015620804. Epub 2016 Jan 5.
PubMed PMID: 26763917.

7: García-Rodiño S, Espasandín-Arias M, Vázquez-Osorio I, Rodríguez-Granados MT.
Photosensitivity associated with systemic triflusal therapy. Photodermatol
Photoimmunol Photomed. 2016 Mar;32(2):113-5. doi: 10.1111/phpp.12226. Epub 2015
Dec 15. PubMed PMID: 26577334.

8: Salerno A, Saurina J, Domingo C. Supercritical CO2 foamed polycaprolactone
scaffolds for controlled delivery of 5-fluorouracil, nicotinamide and triflusal.
Int J Pharm. 2015 Dec 30;496(2):654-63. doi: 10.1016/j.ijpharm.2015.11.012. Epub
2015 Nov 10. PubMed PMID: 26570986.

9: Shin S, Kim KJ, Cho IJ, Hong GR, Jang Y, Chung N, Rah YM, Chang HJ. Effect of
Triflusal on Primary Vascular Dysregulation Compared with Aspirin: A
Double-Blind, Randomized, Crossover Trial. Yonsei Med J. 2015 Sep;56(5):1227-34.
doi: 10.3349/ymj.2015.56.5.1227. PubMed PMID: 26256964; PubMed Central PMCID:
PMC4541651.

10: Ge J, Ding LK, Yang J, Jia YY, Lu CT, Ding Y, Song Y, Song W, Wen AD. Effect
of food on the pharmacokinetics of triflusal and its major active metabolite,
2-hydroxy-4-trifluoromethyl benzoic acid, in healthy subjects. Int J Clin
Pharmacol Ther. 2015 Mar;53(3):272-6. doi: 10.5414/CP202229. PubMed PMID:
25546165.