triflupromazine

• CAT Number: M070990
• CAS Number: 146-54-3
• Molecular Formula: C18H19F3N2S
• Molecular Weight: 352.419
• Purity: ≥95%
• Storage: -20°C
• IUPAC Name: N,N-dimethyl-3-[2-(trifluoromethyl)phenothiazin-10-yl]propan-1-amine
• InChI: InChI=1S/C18H19F3N2S/c1-22(2)10-5-11-23-14-6-3-4-7-16(14)24-17-9-8-13(12-15(17)23)18(19,20)21/h3-4,6-9,12H,5,10-11H2,1-2H3
• InChIKey: XSCGXQMFQXDFCW-UHFFFAOYSA-N
• SMILES: CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)C(F)(F)F

Triflupromazine a medication of the phenothiazine class used as an antipsychotic agent and as an antiemetic.

Reference

1:Effect of long-chain Fatty acids on the binding of triflupromazine to human serum albumin: a spectrophotometric study. Kitamura K, Takegami S, Tanaka R, Omran AA, Kitade T.Sci Pharm. 2013 Dec 28;82(2):233-45. doi: 10.3797/scipharm.1310-23. Print 2014 Apr-Jun. PMID: 24959397 Free PMC Article2:Structural requirements for the antitubercular quaternized triflupromazine pharmacophore. Kunciw DL, Liechty JJ, Mitchell MO, Wan B, Franzblau SG.Bioorg Med Chem Lett. 2012 Sep 1;22(17):5679-80. doi: 10.1016/j.bmcl.2012.06.095. Epub 2012 Jul 6. PMID: 22850215 3:Determination of the partition coefficient of triflupromazine between phosphatidylcholine vesicles and water by (19)F nuclear magnetic resonance spin-lattice relaxation time measurement. Kitamura K, Yamamoto M, Takegami S, Sugiura M.Talanta. 1999 Jun 14;49(2):261-5. PMID: 18967595 4:Effects of inorganic ions on the binding of triflupromazine and chlorpromazine to bovine serum albumin studied by spectrometric methods. Kitamura K, Omran AA, Nagata C, Kamijima Y, Tanaka R, Takegami S, Kitade T.Chem Pharm Bull (Tokyo). 2006 Jul;54(7):972-6. PMID: 16819214 Free Article5:Effects of phosphatidylserine and phosphatidylethanolamine content on partitioning of triflupromazine and chlorpromazine between phosphatidylcholine-aminophospholipid bilayer vesicles and water studied by second-derivative spectrophotometry. Takegami S, Kitamura K, Kitade T, Takashima M, Ito M, Nakagawa E, Sone M, Sumitani R, Yasuda Y.Chem Pharm Bull (Tokyo). 2005 Jan;53(1):147-50. PMID: 15635254 Free Article6:Romifidine-ketamine anaesthesia in atropine and triflupromazine pre-medicated buffalo calves. Sharma AK, Kumar N, Dimri U, Hoque M, Maiti SK, Gupta OP, Shahi A.J Vet Med A Physiol Pathol Clin Med. 2004 Dec;51(9-10):420-4. PMID: 15610485 7:19F NMR spectroscopic study on the binding of triflupromazine to bovine and human serum albumins. Kitamura K, Kume M, Yamamoto M, Takegami S, Kitade T.J Pharm Biomed Anal. 2004 Oct 29;36(2):411-4. PMID: 15496337 8:Triflupromazine: a microbicide non-antibiotic compound. Dastidar SG, Debnath S, Mazumdar K, Ganguly K, Chakrabarty AN.Acta Microbiol Immunol Hung. 2004;51(1-2):75-83. PMID: 15362289 9:Effects of Particle Size and Cholesterol Content on the Partition Coefficients of Chlorpromazine and Triflupromazine between Phosphatidylcholine-Cholesterol Bilayers of Unilamellar Vesicles and Water Studied by Second-Derivative Spectrophotometry. Takegami S, Kitamura K, Kitade T, Hasegawa K, Nishihira A.J Colloid Interface Sci. 1999 Dec 1;220(1):81-87. PMID: 10550243 10:[Phenothiazine derivatives, chlorpromazine and triflupromazine, produce different effects on sympathetic nerve activity in urethane-anesthetized rabbits]. Ogura S.Masui. 1994 Aug;43(8):1179-90. Japanese. PMID: 7933499