Triamcinolone Acetonide

  • CAT Number: A000642
  • CAS Number: 76-25-5
  • Molecular Formula: C24H31FO6
  • Molecular Weight: 434.504
  • Purity: ≥95%
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Triamcinolone Acetonide (Cat No.:A000642) is a hormone drug with anti-inflammatory, anti-allergic, anti-pruritic and capillary constricting effects, which can be used for neurodermatitis, eczema, psoriasis, arthralgia, bronchial asthma and other conditions.

Catalog Number A000642
CAS Number 76-25-5
Synonyms

76-25-5; Azmacort; Aristoderm; Aristogel; Kenalone

Molecular Formula

C24H31FO6

Purity 95%
Storage -20°C
InChI InChI=1S/C24H31FO6/c1-20(2)30-19-10-16-15-6-5-13-9-14(27)7-8-21(13,3)23(15,25)17(28)11-22(16,4)24(19,31-20)18(29)12-26/h7-9,15-17,19,26,28H,5-6,10-12H2,1-4H3/t15-,16-,17-,19+,21-,22-,23-,24+/m0/s1
InChIKey YNDXUCZADRHECN-JNQJZLCISA-N
SMILES CC1(OC2CC3C4CCC5=CC(=O)C=CC5(C4(C(CC3(C2(O1)C(=O)CO)C)O)F)C)C
Reference

1: van Heugten AJP, de Boer W, de Vries WS, Markesteijn CMA, Vromans H.
Development and validation of a stability-indicating HPLC-UV method for the
determination of triamcinolone acetonide and its degradation products in an
ointment formulation. J Pharm Biomed Anal. 2017 Nov 7;149:265-270. doi:
10.1016/j.jpba.2017.11.026. [Epub ahead of print] PubMed PMID: 29127908.
<br>

2: Chauhan P, De D, Handa S, Narang T, Saikia UN. A prospective observational
study to compare efficacy of topical triamcinolone acetonide 0.1% oral paste,
oral methotrexate, and a combination of topical triamcinolone acetonide 0.1% and
oral methotrexate in moderate to severe oral lichen planus. Dermatol Ther. 2017
Nov 10. doi: 10.1111/dth.12563. [Epub ahead of print] PubMed PMID: 29124831.

<br>
3: Al Hinai A, Wali UK, Rasool TA, Rizvi SG. Experience of intravitreal
triamcinolone acetonide for treatment of diabetic macular edema among Omani
population. Oman J Ophthalmol. 2017 Sep-Dec;10(3):177-183. doi:
10.4103/ojo.OJO_173_2016. PubMed PMID: 29118493; PubMed Central PMCID:
PMC5657160.

<br>
4: Aval SF, Zarghami N, Alizadeh E, Mohammadi SA. The effect of ketorolac and
triamcinolone acetonide on adipogenic and hepatogenic differentiation through
miRNAs 16/15/195: Possible clinical application in regenerative medicine. Biomed
Pharmacother. 2017 Nov 1;97:675-683. doi: 10.1016/j.biopha.2017.10.126. [Epub
ahead of print] PubMed PMID: 29101812.

<br>
5: Srivastava S, Patil AN, Prakash C, Kumari H. Comparison of Intralesional
Triamcinolone Acetonide, 5-Fluorouracil, and Their Combination for the Treatment
of Keloids. Adv Wound Care (New Rochelle). 2017 Nov 1;6(11):393-400. doi:
10.1089/wound.2017.0741. PubMed PMID: 29098115; PubMed Central PMCID: PMC5665091.
<br>

6: Conaghan PG, Cohen SB, Berenbaum F, Lufkin J, Johnson JR, Bodick N. Phase 2b
trial of a novel extended-release microsphere formulation of triamcinolone
acetonide for intra-articular injection in knee osteoarthritis. Arthritis
Rheumatol. 2017 Oct 31. doi: 10.1002/art.40364. [Epub ahead of print] PubMed
PMID: 29088579.
<br>

7: Liebmann P, Vorstandlechner V, Radtke C. Comment: A Prospective Randomized
Trial of the Efficacy of Fibrin Glue, Triamcinolone Acetonide and Quilting
Sutures in Seroma Prevention after Latissimus Dorsi Breast Reconstruction. Plast
Reconstr Surg. 2017 Oct 13. doi: 10.1097/PRS.0000000000004032. [Epub ahead of
print] PubMed PMID: 29068895.

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8: Kraus VB, Conaghan PG, Aazami HA, Mehra P, Kivitz AJ, Lufkin J, Hauben J,
Johnson JR, Bodick N. Synovial and systemic pharmacokinetics (PK) of
triamcinolone acetonide (TA) following intra-articular (IA) injection of an
extended-release microsphere-based formulation (FX006) or standard crystalline
suspension in patients with knee osteoarthritis (OA). Osteoarthritis Cartilage.
2017 Oct 9. pii: S1063-4584(17)31226-8. doi: 10.1016/j.joca.2017.10.003. [Epub
ahead of print] PubMed PMID: 29024802.
<br>

9: Ashraf J, Radford AR, Turner A, Subramaniam R. Preliminary Experience with
Instillation of Triamcinolone Acetonide into the Urethra for Idiopathic
Urethritis: A Prospective Pilot Study. J Laparoendosc Adv Surg Tech A. 2017
Nov;27(11):1217-1221. doi: 10.1089/lap.2017.0064. Epub 2017 Oct 12. PubMed PMID:
29023188.
<br>

10: Sar-Pomian M, Czuwara J, Grygorowicz T, Mirowska-Guzel D,
Cudnoch-Jedrzejewska A, Rudnicka L, Olszewska M. Efficacy of perilesional and
intralesional triamcinolone acetonide injections in pemphigus vulgaris lesions of
the scalp: an effective therapeutic option. Clin Exp Dermatol. 2017 Oct 10. doi:
10.1111/ced.13288. [Epub ahead of print] PubMed PMID: 28994133.

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