Trazodone hydrochloride

  • CAT Number: A000996
  • CAS Number: 25332-39-2
  • Molecular Formula: C19H23Cl2N5O
  • Molecular Weight: 408.327
  • Purity: ≥95%
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Trazodone HCl is an antidepressant belonging to the class of serotonin receptor antagonists and reuptake inhibitors for treatment of anxiety disorders. It is a phenylpiperazine compound. Trazodone also has antianxiety (anxiolytic) and sleep-inducing (hypnotic) effects.

Catalog Number A000996
CAS Number 25332-39-2
Molecular Formula

C19H23Cl2N5O

Purity 95%
Target 5-HT Receptor
Solubility Limited solubility
Storage Store at -20°C
IUPAC Name 2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-[1,2,4]triazolo[4,3-a]pyridin-3-one;hydrochloride
InChI InChI=1S/C19H22ClN5O.ClH/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25;/h1-3,5-7,9,15H,4,8,10-14H2;1H
InChIKey OHHDIOKRWWOXMT-UHFFFAOYSA-N
SMILES C1CN(CCN1CCCN2C(=O)N3C=CC=CC3=N2)C4=CC(=CC=C4)Cl.Cl
Reference

1: Stevens BJ, Frantz EM, Orlando JM, Griffith E, Harden LB, Gruen ME, Sherman
BL. Efficacy of a single dose of trazodone hydrochloride given to cats prior to
veterinary visits to reduce signs of transport- and examination-related anxiety.
J Am Vet Med Assoc. 2016 Jul 15;249(2):202-7. doi: 10.2460/javma.249.2.202.
PubMed PMID: 27379596.</br>
2: Yonar D, Sünnet&#231;io&#287;lu MM. Spectroscopic and calorimetric studies on trazodone
hydrochloride-phosphatidylcholine liposome interactions in the presence and
absence of cholesterol. Biochim Biophys Acta. 2014 Oct;1838(10):2369-79. doi:
10.1016/j.bbamem.2014.06.009. Epub 2014 Jun 17. PubMed PMID: 24950245.</br>
3: Xu JX, Gao G, Xu N, Yang YY. [Yimusake alone or combined with trazodone
hydrochloride for primary premature ejaculation]. Zhonghua Nan Ke Xue. 2012
Apr;18(4):376-8. Chinese. PubMed PMID: 22574377.</br>
4: Oleptro&#8482; (trazodone hydrochloride) extended-release tablets. P T. 2011
Feb;36(2):2-18. PubMed PMID: 21431085; PubMed Central PMCID: PMC3059557.</br>
5: Das MK, Ghosal SK. Ex vivo and in vivo evaluation of transdermal formulation
of trazodone hydrochloride. Acta Pol Pharm. 2008 Jul-Aug;65(4):481-6. PubMed
PMID: 19051591.

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