TP-0903

• CAT Number: I001303
• CAS Number: 1341200-45-0
• Molecular Formula: C₂₄H₃₀ClN₇O₂S
• Molecular Weight: 516.06
• Purity: ≥95%
• Target: Axl
• Solubility: DMSO: ≥ 30 mg/mL
• Storage: Store at -20°C
• IUPAC Name: 2-[[5-chloro-2-[4-[(4-methylpiperazin-1-yl)methyl]anilino]pyrimidin-4-yl]amino]-N,N-dimethylbenzenesulfonamide
• InChI: InChI=1S/C24H30ClN7O2S/c1-30(2)35(33,34)22-7-5-4-6-21(22)28-23-20(25)16-26-24(29-23)27-19-10-8-18(9-11-19)17-32-14-12-31(3)13-15-32/h4-11,16H,12-15,17H2,1-3H3,(H2,26,27,28,29)
• InChIKey: YUAALFPUEOYPNX-UHFFFAOYSA-N
• SMILES: CN1CCN(CC1)CC2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4=CC=CC=C4S(=O)(=O)N(C)C)Cl

TP-0903 (Cat.No:I001303) is a small molecule inhibitor that targets the protein tyrosine phosphatase SRC homology region 2 domain-containing phosphatase-1 (SHP-1). It has shown potential in preclinical studies as an anticancer agent, particularly against hematologic malignancies. TP-0903’s ability to inhibit SHP-1 makes it a promising candidate for targeted cancer therapies.

Reference

1:Leuk Lymphoma. 2016;57(6):1494-7. doi: 10.3109/10428194.2015.1102243. Epub 2015 Nov 16. Preclinical combination of TP-0903, an AXL inhibitor and B-PAC-1, a procaspase-activating compound with ibrutinib in chronic lymphocytic leukemia.Patel V,Keating MJ,Wierda WG,Gandhi V, PMID: 26440741 PMCID: PMC4963009 [Available on 2017-06-01] DOI: 10.3109/10428194.2015.1102243