Torin 1

• CAT Number: I000853
• CAS Number: 1222998-36-8
• Molecular Formula: C₃₅H₂₈F₃N₅O₂
• Molecular Weight: 607.62
• Purity: ≥95%
• Synonyms: 1-[4-(4-propanoylpiperazin-1-yl)-3-(trifluoromethyl)phenyl]-9-quinolin-3-ylbenzo[h][1,6]naphthyridin-2-one
• Target: mTOR
• Solubility: DMSO: ≤ 6 mg/mL (Need ultrasonic or warming)
• Storage: 3 years -20C powder
• InChI: InChI=1S/C35H28F3N5O2/c1-2-32(44)42-15-13-41(14-16-42)31-11-9-26(19-28(31)35(36,37)38)43-33(45)12-8-24-20-40-30-10-7-22(18-27(30)34(24)43)25-17-23-5-3-4-6-29(23)39-21-25/h3-12,17-21H,2,13-16H2,1H3
• InChIKey: AKCRNFFTGXBONI-UHFFFAOYSA-N
• SMILES: CCC(=O)N1CCN(CC1)C2=C(C=C(C=C2)N3C(=O)C=CC4=CN=C5C=CC(=CC5=C43)C6=CC7=CC=CC=C7N=C6)C(F)(F)F

Torin 1 (CAT: I000853) is a potent and selective inhibitor of the mammalian target of rapamycin (mTOR). It exerts its action by binding to the ATP-binding site of mTOR, leading to the inhibition of mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2) activities. By blocking these complexes, Torin 1 effectively suppresses the mTOR signaling pathway, which plays a crucial role in regulating cell growth, proliferation, and survival.

Reference

1:Impact on Autophagy and Ultraviolet B Induced Responses of Treatment with the MTOR Inhibitors Rapamycin, Everolimus, Torin 1, and pp242 in Human Keratinocytes. Xu S, Li L, Li M, Zhang M, Ju M, Chen X, Gu H.Oxid Med Cell Longev. 2017;2017:5930639. doi: 10.1155/2017/5930639. Epub 2017 Mar 16. PMID: 28400912 Free PMC Article2:Mammalian target of rapamycin inhibitors, temsirolimus and torin 1, attenuate stemness-associated properties and expression of mesenchymal markers promoted by phorbol-myristate-acetate and oncostatin-M in glioblastoma cells. Chandrika G, Natesh K, Ranade D, Chugh A, Shastry P.Tumour Biol. 2017 Mar;39(3):1010428317695921. doi: 10.1177/1010428317695921. PMID: 28351321 3:Intra-articular injection of Torin 1 reduces degeneration of articular cartilage in a rabbit osteoarthritis model. Cheng NT, Guo A, Cui YP.Bone Joint Res. 2016 Jun;5(6):218-24. doi: 10.1302/2046-3758.56.BJR-2015-0001. PMID: 27301478 Free PMC Article4:The protective role of autophagy in experimental osteoarthritis, and the therapeutic effects of Torin 1 on osteoarthritis by activating autophagy. Cheng NT, Guo A, Meng H.BMC Musculoskelet Disord. 2016 Apr 6;17:150. doi: 10.1186/s12891-016-0995-x. PMID: 27052304 Free PMC Article5:Torin 1 partially corrects vigabatrin-induced mitochondrial increase in mouse. Vogel KR, Ainslie GR, Jansen EE, Salomons GS, Gibson KM.Ann Clin Transl Neurol. 2015 Jun;2(6):699-706. doi: 10.1002/acn3.200. Epub 2015 Apr 17. PMID: 26125044 Free PMC Article6:Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1. Francipane MG, Lagasse E.Oncotarget. 2013 Nov;4(11):1948-62. PMID: 24185040 Free PMC Article