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Toremifene Citrate

Toremifene Citrate

  • CAT Number: A001055
  • CAS Number: 89778-27-8
  • Molecular Formula: C26H28ClNO • C6H8O7
  • Molecular Weight: 598.1
  • Purity: ≥95%
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Toremifene Citrate is an oral selective estrogen receptor modulator (SERM), used in the treatment of advanced breast cancer.<br>Toremifene (7.5 mM) causes approximately 60% of the cells to exhibit morphologic characteristics typical of cells undergoing programmed death, or apoptosis in human breast cancer cells. Toremifene (5-10 mM) results in elevated levels of TRPM-2 and TGF beta 1 mRNAs in in vitro or in vivo grown tumor cells. Toremifene causes growth inhibition of estrogen-sensitive breast cancer cells by inducing some cells to undergo apoptosis and by inhibiting other cells from entering mitosis.<br>Toremifene, at the highest tested dose, increases the incidence of hepatocellular carcinomas in the DEN-initiated groups to a level one-third that observed with Tamoxifen administration to DEN-initiated rats. Toremifene increases the incidence of hypernephromas in previously DEN-initiated rats.

Catalog Number A001055
CAS Number 89778-27-8
Molecular Formula

C26H28ClNO • C6H8O7

Purity 95%
Target Estrogen/progestogen Receptor
Solubility >24.2mg/mL in DMSO
Storage 3 years -20C powder
InChIKey IWEQQRMGNVVKQW-OQKDUQJOSA-N

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